住院儿童与青少年神经性厌食症患者的临床特征。
Clinical Characteristics of Inpatients with Childhood vs. Adolescent Anorexia Nervosa.
机构信息
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, RWTH Aachen, 52074 Aachen, Germany.
出版信息
Nutrients. 2019 Oct 28;11(11):2593. doi: 10.3390/nu11112593.
We aimed to compare the clinical data at first presentation to inpatient treatment of children (<14 years) vs. adolescents (≥14 years) with anorexia nervosa (AN), focusing on duration of illness before hospital admission and body mass index (BMI) at admission and discharge, proven predictors of the outcomes of adolescent AN. Clinical data at first admission and at discharge in 289 inpatients with AN (children: = 72; adolescents: = 217) from a German multicenter, web-based registry for consecutively enrolled patients with childhood and adolescent AN were analyzed. Inclusion criteria were a maximum age of 18 years, first inpatient treatment due to AN, and a BMI <10th BMI percentile at admission. Compared to adolescents, children with AN had a shorter duration of illness before admission (median: 6.0 months vs. 8.0 months, = 0.004) and higher BMI percentiles at admission (median: 0.7 vs. 0.2, = 0.004) as well as at discharge (median: 19.3 vs. 15.1, = 0.011). Thus, in our study, children with AN exhibited clinical characteristics that have been associated with better outcomes, including higher admission and discharge BMI percentile. Future studies should examine whether these factors are actually associated with positive long-term outcomes in children.
我们旨在比较首次就诊时的临床数据与青少年（≥14 岁）和儿童（<14 岁）厌食症患者的住院治疗，重点关注入院前疾病持续时间和入院及出院时的体重指数（BMI），这些都是青少年厌食症结果的已知预测因素。对来自德国多中心、基于网络的儿童和青少年 AN 连续入组患者登记处的 289 名 AN 住院患者（儿童：n=72；青少年：n=217）的首次入院和出院时的临床数据进行了分析。纳入标准为年龄最大 18 岁，首次因 AN 入院治疗，入院时 BMI<第 10 个 BMI 百分位数。与青少年相比，儿童 AN 患者入院前疾病持续时间更短（中位数：6.0 个月 vs. 8.0 个月，=0.004），入院时 BMI 百分位数更高（中位数：0.7 vs. 0.2，=0.004），出院时 BMI 百分位数也更高（中位数：19.3 vs. 15.1，=0.011）。因此，在我们的研究中，患有 AN 的儿童表现出与更好结果相关的临床特征，包括更高的入院和出院 BMI 百分位数。未来的研究应检验这些因素是否与儿童的长期积极结果相关。
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