Expanded Program on Immunization Department, Yunnan Center for Disease Control and Prevention, Kunming, China.
Expanded Program on Immunization Department, Lincang Center for Disease Control and Prevention, Lincang City, Yunnan, China.
Hum Vaccin Immunother. 2020 Apr 2;16(4):881-885. doi: 10.1080/21645515.2019.1673641. Epub 2019 Oct 29.
: A recent measles importation-related outbreak in the China-Myanmar border region required outbreak response immunization to stop the outbreak, raising the question of measles immunity in the area. We conducted two measles serological surveys to develop a seroepidemiological profile of native Chinese citizens and registered Myanmar immigrants to identify strategies to promote measles elimination in the border region.: We conducted a clinic-based measles serosurvey of Myanmar registered immigrants (n = 300) and a population-based serosurvey of Chinese Lincang residents (n = 355). Serum samples were tested with enzyme-linked immunosorbent assays to assess immunity to measles.: We found that Myanmar immigrants had a seropositivity rate of 85.3% (95% : 81.3-89.4) with a GMT of 924.9 mIU/ml, and Lincang Chinese nationals had a seropositivity rate of 94.6% (95% :92.3-97.0) with a GMT of 1363.3 mIU/ml. Myanmar children 2-6 years of age and 7-14 years of age were more likely to be susceptible to measles than same-aged Chinese children: odds ratios 23.00 (95% : 5.10-103.69, < .001) and 7.95 (95% : 1.66-38.01, = .009), respectively.: We recommend conducting a catch-up vaccination program for Myanmar children ≤15 years old.
中国-缅甸边境地区最近发生的麻疹输入性相关疫情需要开展疫情应对免疫接种以阻止疫情,这引发了该地区麻疹免疫情况的问题。我们进行了两项麻疹血清学调查,以建立中国本土公民和登记缅甸移民的血清流行病学概况,确定在边境地区消除麻疹的策略。
我们对登记的缅甸移民(n=300)进行了基于诊所的麻疹血清学调查,对中国临沧居民(n=355)进行了基于人群的血清学调查。采用酶联免疫吸附试验检测血清样本,以评估对麻疹的免疫力。
我们发现,缅甸移民的血清阳性率为 85.3%(95%:81.3-89.4),GMT 为 924.9 mIU/ml,而临沧中国居民的血清阳性率为 94.6%(95%:92.3-97.0),GMT 为 1363.3 mIU/ml。2-6 岁和 7-14 岁的缅甸儿童比同年龄的中国儿童更容易感染麻疹:比值比分别为 23.00(95%:5.10-103.69, <.001)和 7.95(95%:1.66-38.01,=.009)。
我们建议为≤15 岁的缅甸儿童开展补充免疫接种计划。