Department of Genetics, University of Cambridge, Cambridge, UK.
Centre for Ecology and Conservation, University of Exeter, Penryn Campus, Cornwall TR10 9FE, UK.
Proc Biol Sci. 2019 Nov 6;286(1914):20192117. doi: 10.1098/rspb.2019.2117. Epub 2019 Oct 30.
, a common vertically transmitted symbiont, can protect insects against viral infection and prevent mosquitoes from transmitting viral pathogens. For this reason, infected mosquitoes are being released to prevent the transmission of dengue and other arboviruses. An important question for the long-term success of these programmes is whether viruses can evolve to escape the antiviral effects of We have found that altered the outcome of competition between strains of the DCV virus in However, still effectively blocked the virus genotypes that were favoured in the presence of the symbiont. We conclude that did cause an evolutionary response in viruses, but this has little or no impact on the effectiveness of virus blocking.
共生菌,一种常见的垂直传播共生体,可以保护昆虫免受病毒感染,并阻止蚊子传播病毒病原体。出于这个原因,感染共生菌的蚊子被释放出来,以防止登革热和其他虫媒病毒的传播。这些项目长期成功的一个重要问题是,病毒是否能够进化以逃避共生菌的抗病毒作用。我们发现,共生菌改变了 DCV 病毒株之间竞争的结果。然而,共生菌仍然有效地阻止了在共生菌存在时占优势的病毒基因型。我们的结论是,共生菌确实导致了病毒的进化反应,但这对病毒阻断的效果几乎没有影响。