Suppr超能文献

病毒在感染中的进化。

Virus evolution in infected .

机构信息

Department of Genetics, University of Cambridge, Cambridge, UK.

Centre for Ecology and Conservation, University of Exeter, Penryn Campus, Cornwall TR10 9FE, UK.

出版信息

Proc Biol Sci. 2019 Nov 6;286(1914):20192117. doi: 10.1098/rspb.2019.2117. Epub 2019 Oct 30.

Abstract

, a common vertically transmitted symbiont, can protect insects against viral infection and prevent mosquitoes from transmitting viral pathogens. For this reason, infected mosquitoes are being released to prevent the transmission of dengue and other arboviruses. An important question for the long-term success of these programmes is whether viruses can evolve to escape the antiviral effects of We have found that altered the outcome of competition between strains of the DCV virus in However, still effectively blocked the virus genotypes that were favoured in the presence of the symbiont. We conclude that did cause an evolutionary response in viruses, but this has little or no impact on the effectiveness of virus blocking.

摘要

共生菌,一种常见的垂直传播共生体,可以保护昆虫免受病毒感染,并阻止蚊子传播病毒病原体。出于这个原因,感染共生菌的蚊子被释放出来,以防止登革热和其他虫媒病毒的传播。这些项目长期成功的一个重要问题是,病毒是否能够进化以逃避共生菌的抗病毒作用。我们发现,共生菌改变了 DCV 病毒株之间竞争的结果。然而,共生菌仍然有效地阻止了在共生菌存在时占优势的病毒基因型。我们的结论是,共生菌确实导致了病毒的进化反应,但这对病毒阻断的效果几乎没有影响。

相似文献

1
Virus evolution in infected .
Proc Biol Sci. 2019 Nov 6;286(1914):20192117. doi: 10.1098/rspb.2019.2117. Epub 2019 Oct 30.
2
-Conferred Antiviral Protection Is Determined by Developmental Temperature.
mBio. 2021 Oct 26;12(5):e0292320. doi: 10.1128/mBio.02923-20. Epub 2021 Sep 7.
4
The Impact of Wolbachia on Virus Infection in Mosquitoes.
Viruses. 2015 Nov 4;7(11):5705-17. doi: 10.3390/v7112903.
5
Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains.
PLoS Pathog. 2014 Sep 18;10(9):e1004369. doi: 10.1371/journal.ppat.1004369. eCollection 2014 Sep.
6
Variation in antiviral protection mediated by different Wolbachia strains in Drosophila simulans.
PLoS Pathog. 2009 Nov;5(11):e1000656. doi: 10.1371/journal.ppat.1000656. Epub 2009 Nov 13.
7
Age, tissue, genotype and virus infection regulate Wolbachia levels in Drosophila.
Mol Ecol. 2020 Jun;29(11):2063-2079. doi: 10.1111/mec.15462. Epub 2020 May 26.
8
The Antiviral Effects of the Symbiont Bacteria in Insects.
Front Immunol. 2021 Jan 29;11:626329. doi: 10.3389/fimmu.2020.626329. eCollection 2020.
10

引用本文的文献

1
Experimental assessment of 3D-printed traps and chemical attractants for the collection of wild .
Fly (Austin). 2025 Dec;19(1):2502184. doi: 10.1080/19336934.2025.2502184. Epub 2025 May 14.
2
3
The infectivity of virus particles from Wolbachia-infected Drosophila.
BMC Microbiol. 2025 Jan 16;25(1):25. doi: 10.1186/s12866-024-03722-6.
4
Wolbachia-mediated resistance to Zika virus infection in Aedes aegypti is dominated by diverse transcriptional regulation and weak evolutionary pressures.
PLoS Negl Trop Dis. 2023 Oct 2;17(10):e0011674. doi: 10.1371/journal.pntd.0011674. eCollection 2023 Oct.
5
Genome evolution of dengue virus serotype 1 under selection by in mosquitoes.
Virus Evol. 2023 Mar 3;9(1):vead016. doi: 10.1093/ve/vead016. eCollection 2023.
8
Investigating the outcomes of virus coinfection within and across host species.
PLoS Pathog. 2023 May 22;19(5):e1011044. doi: 10.1371/journal.ppat.1011044. eCollection 2023 May.
10
-Virus interactions and arbovirus control through population replacement in mosquitoes.
Pathog Glob Health. 2023 May;117(3):245-258. doi: 10.1080/20477724.2022.2117939. Epub 2022 Oct 7.

本文引用的文献

1
Sustained -mediated blocking of dengue virus isolates following serial passage in cell culture.
Virus Evol. 2019 Jun 8;5(1):vez012. doi: 10.1093/ve/vez012. eCollection 2019 Jan.
2
Scaled deployment of to protect the community from dengue and other  transmitted arboviruses.
Gates Open Res. 2019 Aug 13;2:36. doi: 10.12688/gatesopenres.12844.3. eCollection 2018.
3
No detectable effect of Mel on the prevalence and abundance of the RNA virome of .
Proc Biol Sci. 2018 Jul 25;285(1883):20181165. doi: 10.1098/rspb.2018.1165.
4
Host shifts result in parallel genetic changes when viruses evolve in closely related species.
PLoS Pathog. 2018 Apr 12;14(4):e1006951. doi: 10.1371/journal.ppat.1006951. eCollection 2018 Apr.
6
Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes aegypti.
PLoS Biol. 2017 May 30;15(5):e2001894. doi: 10.1371/journal.pbio.2001894. eCollection 2017 May.
8
Biological Control of Mosquito Vectors: Past, Present, and Future.
Insects. 2016 Oct 3;7(4):52. doi: 10.3390/insects7040052.
9
Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes.
Cell Host Microbe. 2016 Jun 8;19(6):771-4. doi: 10.1016/j.chom.2016.04.021. Epub 2016 May 4.
10
Wolbachia Blocks Viral Genome Replication Early in Infection without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways.
PLoS Pathog. 2016 Apr 18;12(4):e1005536. doi: 10.1371/journal.ppat.1005536. eCollection 2016 Apr.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验