Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan
Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Hokkaido, Japan.
In Vivo. 2019 Nov-Dec;33(6):2095-2102. doi: 10.21873/invivo.11709.
BACKGROUND/AIM: Abnormal expression of CD44 may promote cancer invasion. However, a limited number of studies have investigated the expression of CD44 in soft tissue sarcoma such as myxofibrosarcoma. We evaluated the relationship between expression of the standard form of CD44 (CD44s) and the clinical course of myxofibrosarcoma.
Forty-four myxofibrosarcoma patients were retrospectively enrolled. Patient information including the proportion of CD44s-positive cells was collected, and multivariate analyses were conducted to determine the relationship between CD44s expression and clinicopathological factors.
Although CD44s did not affect prognosis, multivariate analysis indicated that high expression of CD44s predicted poor event-free survival (p=0.004) and local recurrence (p=0.049). CD44s expression was not associated with the occurrence of distant metastasis but was significantly higher in those with lung metastasis (p=0.044).
Increased expression of CD44s predicted poor event-free survival and local recurrence and was observed in myxofibrosarcoma patients with lung metastasis.
背景/目的：CD44 的异常表达可能促进癌症侵袭。然而，仅有少数研究调查了 CD44 在黏液纤维肉瘤等软组织肉瘤中的表达。我们评估了标准型 CD44（CD44s）的表达与黏液纤维肉瘤临床病程之间的关系。
回顾性纳入 44 例黏液纤维肉瘤患者。收集了包括 CD44s 阳性细胞比例在内的患者信息，并进行了多变量分析，以确定 CD44s 表达与临床病理因素之间的关系。
尽管 CD44s 对预后没有影响，但多变量分析表明，CD44s 的高表达预示着无事件生存（p=0.004）和局部复发（p=0.049）较差。CD44s 的表达与远处转移的发生无关，但在发生肺转移的患者中明显更高（p=0.044）。
CD44s 的表达增加预示着无事件生存和局部复发较差，并且在发生肺转移的黏液纤维肉瘤患者中观察到。
