Jeyadevan Ashani, Bakeberg Megan C, Byrnes Michelle, Kenna Jade, Ghosh Soumya, Stell Rick, Walters Sue, Evans Tess, McGregor Sarah, Horne Malcolm, Mastaglia Frank L, Anderton Ryan S
School of Health Sciences, University of Notre Dame Australia, Fremantle, WA, Australia.
Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
Parkinsons Dis. 2019 Oct 1;2019:2672075. doi: 10.1155/2019/2672075. eCollection 2019.
Patients with Parkinson's disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. This study investigated whether trait impulsivity associates with mild cognitive impairment (MCI), or is altered in a PD patient cohort with MCI.
A total of 302 patients with idiopathic PD were recruited sequentially from three Australian Movement Disorder clinics. Based on cognitive scores, participants were divided into two groups, one defined as having mild cognitive impairment (PD-MCI; = 113) and the other with normal cognitive function (PD-C; = 189). Trait impulsivity was evaluated using the Barrett Impulsiveness Scale 11 (BIS-11). Total impulsivity scores, as well as subscale scores, were compared between PD-C and PD-MCI groups.
The PD-MCI cohort had significantly lower scores in all cognitive domains, and mirrored expected clinical differences in medication, motor symptoms, and disease duration, when compared to the PD-C cohort. Self-reported impulsivity was not significantly different between groups, nor was there a difference within first-order subscale scores: attention (=0.137), cognitive instability (=0.787), self-control (=0.503), cognitive complexity (=0.157), motor impulsivity (=0.559), or perseverance (=0.734) between the PD-MCI and PD-C groups.
These findings suggest that impulsive traits and behaviors are independent of changes in cognitive state and are not altered in PD patients with mild cognitive impairment.
帕金森病（PD）患者常出现认知缺陷，部分患者还会发展为冲动控制障碍（ICD）；然而，冲动性与认知功能障碍之间的关系仍不明确。本研究调查了特质冲动性是否与轻度认知障碍（MCI）相关，或在患有MCI的PD患者队列中是否发生改变。
从澳大利亚的三家运动障碍诊所连续招募了302例特发性PD患者。根据认知评分，参与者被分为两组，一组被定义为患有轻度认知障碍（PD-MCI；n = 113），另一组认知功能正常（PD-C；n = 189）。使用巴雷特冲动性量表11（BIS-11）评估特质冲动性。比较PD-C组和PD-MCI组的总冲动性得分以及子量表得分。
与PD-C队列相比，PD-MCI队列在所有认知领域的得分均显著较低，并且在药物治疗、运动症状和病程方面反映出预期的临床差异。两组之间自我报告的冲动性没有显著差异，一阶子量表得分也没有差异：PD-MCI组和PD-C组之间的注意力（P = 0.137）、认知不稳定性（P = 0.787）、自我控制（P = 0.503）、认知复杂性（P = 0.157）、运动冲动性（P = 0.559）或坚持性（P = 0.734）。
这些发现表明，冲动特质和行为独立于认知状态的变化，并且在患有轻度认知障碍的PD患者中没有改变。
