Bakeberg Megan C, Riley Maddeson, Byrnes Michelle, Jefferson Alexa, Ghosh Souyma, Horne Malcom K, McGregor Sarah, Stell Rick, Walters Sue, Evans Tess, Roberts Katherine, Mastaglia Frank L, Anderton Ryan S
Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia.
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, Western Australia, Australia.
Parkinsons Dis. 2020 Sep 30;2020:8296203. doi: 10.1155/2020/8296203. eCollection 2020.
Heightened impulsivity has been reported in a subset of people with Parkinson's disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity.
To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP.
The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP. Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (>75th percentile) were significantly predictive of BIS-11 scores.
Serum ceruloplasmin was higher in females with PD ( < 0.001) and associated with MDS-UPDRS III, Hoehn and Yahr, and ACE-R scores ( < 0.05). When correcting for covariates, higher serum ceruloplasmin concentrations were associated with the 2 order nonplanning impulsivity and with the 1st order self-control and cognitive complexity impulsivity domains.
Higher serum ceruloplasmin levels are independently associated with heightened nonplanning impulsivity in PwP. Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD.
据报道，一部分帕金森病患者（PwP）存在冲动性增强的情况，且被认为是冲动控制障碍（ICD）发生的一个风险因素。然而，目前尚无公认的冲动性增强的生化标志物。
确定血清铜蓝蛋白（一种参与铁和铜稳态调节的血清标志物）是否与帕金森病患者的特质冲动性相关。
本研究在一个由214名帕金森病患者组成的澳大利亚队列中，使用巴拉特冲动性量表（BIS-11）测量血清铜蓝蛋白和冲动性。采用多变量一般线性模型（GLM）来确定较高的血清铜蓝蛋白水平（>第75百分位数）是否能显著预测BIS-11评分。
帕金森病女性患者的血清铜蓝蛋白水平较高（<0.001），且与MDS-UPDRS III、Hoehn和Yahr以及ACE-R评分相关（<0.05）。在校正协变量后，较高的血清铜蓝蛋白浓度与二阶非计划性冲动性以及一阶自我控制和认知复杂性冲动性领域相关。
较高的血清铜蓝蛋白水平与帕金森病患者非计划性冲动性增强独立相关。因此，血清铜蓝蛋白水平可能具有临床实用性，可作为帕金森病患者冲动性增强的标志物。
