Section of Psychology - Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), University of Florence, Florence, Italy.
Unit of Neurology of Florence, Cerebrovascular and Neurodegenerative Disease Area of the Department of Medical Specialties, Central Tuscany Local Health Authority, Florence, Italy.
Neurol Sci. 2022 Jan;43(1):335-340. doi: 10.1007/s10072-021-05325-9. Epub 2021 May 28.
In patients with Parkinson's disease (PD), impulsivity is still a matter of investigation. It has been hypothesized that impulsive personality traits may favour impulse control disorder (ICD) onset during dopaminergic therapy. In healthy subjects, a relationship between the awareness of motor intention and impulsive personality traits assessed by the Barratt impulsivity scale (BIS-11) has been reported. The aim of this study was to evaluate the relationship between the awareness of voluntary action and impulsivity traits in PD.
Twenty-eight PD patients (stages I-III on the Hoehn and Yahr scale) underwent an impulsivity trait assessment by the BIS-11 scale and a task based on the Libet's clock. Participants were requested to perform a self-initiated movement and report the time they first feel their intention to move (W-judgement) or the time of the actual movement (M-judgement).
In patients with higher BIS-11 scores, the time lag between the W-judgement and the actual movement was significantly lower than in patients with lower BIS-11. No difference emerged in the M-judgement.
Data suggest that also in PD patients, the impulsive personality trait is related to a "delayed" awareness of motor intention and therefore to a shorter interval to allow a conscious "veto" of the impending action. Characterization of the temporal profile of awareness of motor intention could prove useful in identifying PD patients at risk of developing ICDs during dopaminergic treatment.
在帕金森病（PD）患者中，冲动仍然是一个研究课题。有人假设冲动的人格特质可能会在多巴胺治疗期间导致冲动控制障碍（ICD）的发生。在健康受试者中，已经报道了运动意图意识与巴雷特冲动量表（BIS-11）评估的冲动人格特质之间的关系。本研究旨在评估 PD 患者中自愿运动意识与冲动特质之间的关系。
28 名 PD 患者（Hoehn 和 Yahr 量表 I-III 期）接受了 BIS-11 量表的冲动特质评估和基于 Libet 时钟的任务。要求参与者进行自主运动，并报告他们第一次感觉到运动意图的时间（W-判断）或实际运动的时间（M-判断）。
在 BIS-11 评分较高的患者中，W-判断与实际运动之间的时间差明显低于 BIS-11 评分较低的患者。M-判断没有差异。
数据表明，在 PD 患者中，冲动的人格特质与运动意图的“延迟”意识有关，因此与允许有意识地“否决”即将发生的行动的间隔更短。运动意图意识的时间特征的描述可能有助于识别在多巴胺治疗期间易发生 ICD 的 PD 患者。
