Yasuhara Ryo, Shibazaki Shunichi, Yamanouchi Takayoshi
Tokyo Medical and Dental University Hospital Faculty of Medicine, Tokyo, Japan.
Department of Emergency and General Internal Medicine, Hitachinaka General Hospital, Hitachinaka, Japan.
Case Rep Infect Dis. 2019 Sep 22;2019:4380429. doi: 10.1155/2019/4380429. eCollection 2019.
Jaundice, conjunctival hyperemia, and acute kidney injury (AKI) are the characteristics of leptospirosis. However, it is not well known that infection can have a clinical picture similar to that of leptospirosis. A 38-year-old man was admitted with jaundice, conjunctival hyperemia, and AKI for 7 days. Chest CT scan showed multiple pulmonary nodules, atypical for leptospirosis. We started treatment with IV piperacillin-tazobactam and minocycline. He became anuric and was urgently started on hemodialysis on the second hospital day. Later on, blood cultures grew and other anaerobic bacteria. Antibody and PCR assays for were negative. We narrowed the antibiotics to IV ceftriaxone and metronidazole. He responded well to the treatment and was discharged on the 18th hospital day. infection is known to cause mixed infection with other anaerobic bacteria. The resistance of many anaerobic bacteria continues to progress, and itself sometimes produces -lactamase. This case highlights the potential risks of using penicillin before diagnosis of leptospirosis.
黄疸、结膜充血和急性肾损伤(AKI)是钩端螺旋体病的特征。然而,尚不清楚 感染可出现与钩端螺旋体病相似的临床表现。一名38岁男性因黄疸、结膜充血和AKI入院7天。胸部CT扫描显示多个肺结节,这在钩端螺旋体病中并不典型。我们开始使用静脉注射哌拉西林-他唑巴坦和米诺环素进行治疗。他出现无尿,并在住院第二天紧急开始血液透析。后来,血培养生长出 及其他厌氧菌。针对 的抗体和PCR检测均为阴性。我们将抗生素调整为静脉注射头孢曲松和甲硝唑。他对治疗反应良好,并于住院第18天出院。已知 感染会导致与其他厌氧菌的混合感染。许多厌氧菌的耐药性持续进展,并且 本身有时会产生β-内酰胺酶。该病例突出了在诊断钩端螺旋体病之前使用青霉素的潜在风险。