Manoharan Harish, Selvarajan Sribal, Sridharan K S, Sekar Uma
Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
Case Rep Infect Dis. 2019 Oct 1;2019:5184386. doi: 10.1155/2019/5184386. eCollection 2019.
Pulmonary infections are the most common clinical manifestations of species. There is an increase in cases of nocardial infections occurring worldwide attributable to the increase in the immunosuppressed population. The availability of molecular methods has aided the detection of more number of cases as well as unusual species. Still, it remains one of the most underdiagnosed pathogens. Recognition of drug resistance in this organism has now mandated early and precise identification with speciation for effective treatment and management. Nocardial species identity can predict antimicrobial susceptibility and guide clinical management. Here, we report two cases of pulmonary nocardiosis caused by unusual species of , namely, and identified by 16S rRNA gene-based sequencing. These cases are being reported for their rarity.
肺部感染是该菌种最常见的临床表现。由于免疫抑制人群的增加,全球诺卡菌感染病例有所上升。分子方法的应用有助于发现更多病例以及不常见的菌种。尽管如此,它仍是诊断最不足的病原体之一。目前,认识到该病原体的耐药性后,需要早期精确鉴定并进行菌种鉴定,以实现有效的治疗和管理。诺卡菌的菌种鉴定可以预测抗菌药物敏感性并指导临床管理。在此,我们报告两例由不常见的诺卡菌种引起的肺诺卡菌病病例,即通过基于16S rRNA基因的测序鉴定出的[具体菌种1]和[具体菌种2]。报告这些病例是因其罕见性。