Thulin L, Tydén G, Samnegård H, Muhrbeck O, Efendić S
Acta Chir Scand. 1979;145(6):395-8.
Cyclic somatostatin was administered intravenously on eight occasions to five consecutive patients with massive haemalemesis due to oesophageal varices. The doses administered with 0--250 micrograms as bolus, followed by 100--250 micrograms per hr during 2--12 hrs. The source of bleeding was determined by endoscopy. The volume of bleeding was estimated from the clinical condition of the patient and by gastric irrigation and iced water. The bleeding stopped immediately on all occasions when somatostatin was administered. It is suggested that the effect is due to the ability of somatostatin to reduce regional splanchnic blood flows and portal pressure.
对5例因食管静脉曲张导致大量上消化道出血的连续患者，8次静脉注射环孢素生长抑素。推注剂量为0 - 250微克，随后在2 - 12小时内每小时注射100 - 250微克。通过内镜检查确定出血来源。根据患者的临床状况以及胃灌洗和冰水来估计出血量。每次注射生长抑素后出血均立即停止。提示这种效果是由于生长抑素能够减少内脏区域血流量和门静脉压力。
