Department of Tissue Engineering, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cell Physiol. 2020 May;235(5):4217-4226. doi: 10.1002/jcp.29376. Epub 2019 Oct 29.
Premature ovarian failure (POF) usually happens former to the age of 40 and affects the female physiological state premenopausal period. In this condition, ovaries stop working long before the expected menopausal time. Of diagnostic symptoms of the disease, one can mention amenorrhea and hypoestrogenism. The cause of POF in most cases is idiopathic; however, cancer therapy may also cause POF. Commonly utilized therapies such as hormone therapy, in-vitro activation, and regenerative medicine are the most well-known treatments for POF. Hence, these therapies may be associated with some complications. The aim of the present study is to discuss the beneficial effects of tissue engineering for fertility rehabilitation in patients with POF as a newly emerging therapy.
卵巢早衰（POF）通常发生在 40 岁之前，影响女性绝经前的生理状态。在这种情况下，卵巢在预期绝经时间之前很早就停止工作。该疾病的诊断症状包括闭经和雌激素水平低下。大多数情况下，POF 的原因是特发性的；然而，癌症治疗也可能导致 POF。常用的治疗方法，如激素治疗、体外激活和再生医学，是 POF 的最知名治疗方法。因此，这些治疗方法可能与一些并发症有关。本研究旨在讨论组织工程作为一种新兴疗法对 POF 患者生育康复的有益影响。
