Department of Health Promotion Science, Sophiahemmet University, Stockholm, Sweden.
Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.
Phys Sportsmed. 2020 May;48(2):222-228. doi: 10.1080/00913847.2019.1684811. Epub 2019 Nov 12.
: To investigate the associations between objectively measured sedentary behavior (SB), light-intensity physical activity (LIPA) and moderate-to-vigorous physical activity (MVPA) and cardiometabolic and endocrine biomarkers, and to estimate the associations of reallocating time from one behavior to another with cardiometabolic and endocrine biomarkers.: Baseline data from participants diagnosed with prediabetes or type 2 diabetes, n = 175, 58% men, mean (SD) age = 64.4 (7.7), recruited to a physical activity intervention was used. Time spent in SB, LIPA and MVPA was measured by accelerometer and transformed into isometric log-ratio coordinates. The associations between time spent in SB, LIPA and MVPA and biomarkers were examined by linear regression models. The change in each outcome of reallocating time between the three behaviors was estimated.: The findings show strong positive associations of time spent in MVPA and negative associations of time spent in SB relative to time spent in the other behaviors with sagittal abdominal diameter (SAD) and homeostasis model assessment for insulin resistance (HOMA-IR) and negative associations of time spent in SB with high-density lipoprotein (HDL) cholesterol. Theoretically, reallocation of 19 minutes MVPA to SB or to LIPA was associated with a 17% and 17% larger SAD, 39% and 36% larger HOMA-IR values and 3.3% and 2.3% lower levels of HDL, respectively.: In conclusion, our analysis from a time-use perspective supports the current evidence that sedentary time is devastating for the cardiometabolic health. While LIPA probably requires more time, maintaining or increasing time in MVPA are the most important features of the time use behaviors when promoting a favorable cardiometabolic risk profile in adults with prediabetes and type 2 diabetes.: ClinicalTrials.gov, NCT02374788. Registered 2 March 2015 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02374788.
: 为了研究客观测量的久坐行为（SB）、低强度体力活动（LIPA）和中高强度体力活动（MVPA）与心血管代谢和内分泌生物标志物的关联，并估计将时间从一种行为重新分配到另一种行为与心血管代谢和内分泌生物标志物的关联：使用了患有前驱糖尿病或 2 型糖尿病的参与者的基线数据，n = 175，男性占 58%，平均（SD）年龄 = 64.4（7.7），招募参加体力活动干预。通过加速度计测量 SB、LIPA 和 MVPA 所花费的时间，并将其转换为等距对数比例坐标。通过线性回归模型检查 SB、LIPA 和 MVPA 所花费的时间与生物标志物之间的关联。通过重新分配三种行为之间的时间来估计每种结果的变化。: 研究结果表明，MVPA 所花费的时间与 SAD（矢状腹部直径）和 HOMA-IR（胰岛素抵抗的稳态模型评估）呈正相关，与 SB 所花费的时间呈负相关，而 SB 所花费的时间与高密度脂蛋白（HDL）胆固醇呈负相关。理论上，将 19 分钟的 MVPA 重新分配到 SB 或 LIPA 中，会使 SAD 增加 17%和 17%，HOMA-IR 值增加 39%和 36%，HDL 水平降低 3.3%和 2.3%。: 总之，从时间利用的角度分析，我们的分析支持了当前的证据，即久坐时间对心血管代谢健康是毁灭性的。虽然 LIPA 可能需要更多的时间，但在促进前驱糖尿病和 2 型糖尿病成年人有利的心血管代谢风险特征时，保持或增加 MVPA 时间是时间利用行为的最重要特征。: ClinicalTrials.gov，NCT02374788。于 2015 年 3 月 2 日注册 - 回顾性注册，https://clinicaltrials.gov/ct2/show/NCT02374788。
