Aydemir Duygu, Karabulut Gözde, Gok Muslum, Barlas Nurhayat, Ulusu Nuriye Nuray
Koc University, School of Medicine, Department of Medical Biochemistry, Sariyer, 34450, Istanbul, Turkey.
Koç University Research Center for Translational Medicine (KUTTAM), Sariyer, 34450, Istanbul, Turkey.
Data Brief. 2019 Sep 17;26:104526. doi: 10.1016/j.dib.2019.104526. eCollection 2019 Oct.
Di (2-ethylhexyl) phthalate (DEHP) is used as plasticizer in the industry and belongs to the phthalate family which can induce tissue damage including kidney, liver, and testis as a result of elevated oxidative stress levels. Glutathione reductase (GR), Glucose-6-phosphate dehydrogenase (G6PD), glutathione S-transferase (GST), 6-phosphogluconate dehydrogenase (6PGD), enzyme activities, trace element and mineral levels were evaluated in the brain and testis tissue samples. Our data revealed that, antioxidant enzyme activities in the brain and testis samples were statistically insignificant in the DEHP administered groups compared to the control group except 400 mg/kg/day DEHP dose group in the testis samples. DEHP can disrupt trace element and mineral levels unlike antioxidant enzyme levels that may due to blood-brain and testis-blood barrier and/or short-term exposure to the DEHP. For more detailed information than the data presented in this article, please see the research article "Impact of the Di (2-Ethylhexyl) Phthalate Administration on Trace Element and Mineral Levels in Relation of Kidney and Liver Damage in Rats" [1].
邻苯二甲酸二（2-乙基己基）酯（DEHP）在工业上用作增塑剂，属于邻苯二甲酸酯类，由于氧化应激水平升高，它可导致包括肾脏、肝脏和睾丸在内的组织损伤。对大脑和睾丸组织样本中的谷胱甘肽还原酶（GR）、葡萄糖-6-磷酸脱氢酶（G6PD）、谷胱甘肽S-转移酶（GST）、6-磷酸葡萄糖酸脱氢酶（6PGD）、酶活性、微量元素和矿物质水平进行了评估。我们的数据显示，与对照组相比，在给予DEHP的组中，大脑和睾丸样本中的抗氧化酶活性在统计学上无显著差异，但睾丸样本中400mg/kg/天DEHP剂量组除外。与抗氧化酶水平不同，DEHP可能由于血脑屏障和血睾屏障以及/或短期接触DEHP而破坏微量元素和矿物质水平。有关比本文所呈现数据更详细的信息，请参阅研究文章《邻苯二甲酸二（2-乙基己基）酯给药对大鼠肾脏和肝脏损伤相关微量元素和矿物质水平的影响》[1]。
