Zhang Kun, Qu Ge, Liu Weidong, Sun Zhoutong
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Sheng Wu Gong Cheng Xue Bao. 2019 Oct 25;35(10):1806-1818. doi: 10.13345/j.cjb.190222.
Industrial enzymes are the "chip" of modern bio-industries, supporting tens- and hundreds-fold of downstream industries development. Elucidating the relationships between enzyme structures and functions is fundamental for industrial applications. Recently, with the advanced developments of protein crystallization and computational simulation technologies, the structure-function relationships have been extensively studied, making the rational design and de novo design become possible. This paper reviews the progress of structure-function relationships of industrial enzymes and applications, and address future developments.
工业酶是现代生物产业的“芯片”,支撑着数十倍乃至数百倍的下游产业发展。阐明酶的结构与功能之间的关系是工业应用的基础。近年来,随着蛋白质结晶和计算模拟技术的不断发展,酶的结构与功能关系得到了广泛研究,使得合理设计和从头设计成为可能。本文综述了工业酶结构与功能关系及其应用的研究进展,并展望了未来的发展方向。