Neuroimmunology of Sepsis Laboratory, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508, Brazil.
Thermoregulation and Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.
Trends Endocrinol Metab. 2019 Dec;30(12):875-878. doi: 10.1016/j.tem.2019.08.012. Epub 2019 Oct 25.
Host defense relies not only on microbicidal mechanisms (resistance), but also on management of collateral damage (tolerance). Here, we discuss how this immunology concept converges with a physiology-born theory on the dichotomy of thermometabolic responses in infection (fever versus hypothermia), yielding a model of immunity that transcends discipline barriers.
宿主防御不仅依赖于杀菌机制（抵抗力），还依赖于对附带损伤的管理（耐受性）。在这里，我们讨论了这一免疫学概念如何与生理学上关于感染时热代谢反应二分性（发热与低体温）的理论相吻合，从而产生了一种超越学科障碍的免疫模型。
