从 Penicillum herquei JX4 中提取的具有生物活性的对乙酰氨基酚衍生物。
Bioactive acetaminophen derivatives from Penicillum herquei JX4.
机构信息
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China; Key Lab of Functional Molecular Engineering of Guangdong Province, South China University of Technology, Guangzhou 510641, People's Republic of China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China.
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China.
出版信息
Fitoterapia. 2019 Nov;139:104400. doi: 10.1016/j.fitote.2019.104400. Epub 2019 Nov 6.
Two novel epimer pairs of acetaminophen derivatives penicilquei A-D (1-4) were isolated from Penicillium herquei JX4. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configurations of penicilquei A-D (1-4) were determined by modifified Mosher's method, and comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Penicilquei A-D (1-4) are the first example of acetaminophen derivatives featuring an unprecedented carbon skeleton. The inhibitory activities of all compounds against nine phytopathogenic fungi and α-glucosidase were evaluated. Penicilquei A-D (1-4) showed strong inhibitory activities against at least eight phytopathogenic fungus.
从青霉属JX4 中分离得到两种新型的对乙酰氨基酚衍生物 epimer 对——penicilquei A-D（1-4）。采用综合光谱方法阐明了它们的结构。通过改进的 Mosher 法和比较它们的实验和计算的电子圆二色谱（ECD）光谱确定了 penicilquei A-D（1-4）的绝对构型。penicilquei A-D（1-4）是具有前所未有的碳骨架的对乙酰氨基酚衍生物的第一个例子。评估了所有化合物对九种植物病原真菌和α-葡萄糖苷酶的抑制活性。penicilquei A-D（1-4）对至少八种植物病原真菌表现出强烈的抑制活性。
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