源自红树林真菌枝孢菌属 Cladosporium sp. JJM22 的生物活性环己烯衍生物。
Bioactive cyclohexene derivatives from a mangrove-derived fungus Cladosporium sp. JJM22.
作者信息
Zhang Bin, Wu Jia-Ting, Zheng Cai-Juan, Zhou Xue-Ming, Yu Zhang-Xin, Li Wan-Shan, Chen Guang-Ying, Zhu Guo-Yuan
机构信息
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China; Department of Chemistry, Guangdong University of Education, Guangzhou 510800, China.
出版信息
Fitoterapia. 2021 Mar;149:104823. doi: 10.1016/j.fitote.2020.104823. Epub 2020 Dec 30.
Four new cyclohexene derivatives cladoscyclitols A-D (1-4) and one new ribofuranose phenol derivative 4-O-α-D-ribofuranose-2-pentyl-3-phemethylol (5) were obtained from the EtOAC extract of the mangrove-derived endophytic fungus Cladosporium sp. JJM22. The structures were elucidated by extensive NMR and MS analysis, while the absolute configurations of the stereogenic carbons were established based on quantum-chemical electronic circular dichroism calculations or comparison of the optical rotations with those of related compounds. Compounds 2 and 5 displayed potent inhibitory activity against α-glucosidase with the IC values of 2.95 and 2.05 μM, respectively.
从源自红树林的内生真菌枝孢菌属JJM22的乙酸乙酯提取物中获得了四种新的环己烯衍生物枝孢环糖醇A - D（1 - 4）和一种新的呋喃核糖酚衍生物4 - O-α-D-呋喃核糖-2-戊基-3-苯甲醇（5）。通过广泛的核磁共振（NMR）和质谱（MS）分析阐明了其结构，同时基于量子化学电子圆二色性计算或与相关化合物旋光度的比较确定了手性碳的绝对构型。化合物2和5对α-葡萄糖苷酶表现出强效抑制活性，其IC值分别为2.95和2.05 μM。
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