微小 RNA 在炎症性心脏病和脓毒症性心功能障碍中的作用：未来的潜在应用？
MicroRNAs in Inflammatory Heart Diseases and Sepsis-Induced Cardiac Dysfunction: A Potential Scope for the Future?
机构信息
Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, 40225 Duesseldorf, Germany.
出版信息
Cells. 2019 Oct 30;8(11):1352. doi: 10.3390/cells8111352.
BACKGROUND
MicroRNAs (miRNAs) are small, single-stranded RNA sequences that regulate gene expression on a post-transcriptional level. In the last few decades, various trials have investigated the diagnostic and therapeutic potential of miRNAs in several disease entities. Here, we provide a review of the available evidence on miRNAs in inflammatory heart diseases (myocarditis, endocarditis, and pericarditis) and sepsis-induced cardiac dysfunction.
METHODS
Systematic database research using the PubMed and Medline databases was conducted between July and September 2019 using predefined search terms. The whole review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
RESULTS
In total, 131 studies were screened, 96 abstracts were read, and 69 studies were included in the review.
DISCUSSION
In the future, circulating miRNAs could serve as biomarkers for diagnosis and disease monitoring in the context of inflammatory heart diseases and sepsis-induced cardiac dysfunction. Considering the promising results of different animal models, certain miRNAs could also emerge as novel therapeutic approaches in this setting.
背景
微小 RNA（miRNAs）是小的、单链 RNA 序列，在转录后水平调节基因表达。在过去的几十年中，各种试验已经研究了 miRNAs 在几种疾病实体中的诊断和治疗潜力。在这里，我们提供了关于在炎症性心脏病（心肌炎、心内膜炎和心包炎）和脓毒症引起的心功能障碍中 miRNAs 的现有证据的综述。
方法
使用预定义的搜索词，在 2019 年 7 月至 9 月期间在 PubMed 和 Medline 数据库中进行系统的数据库研究。整个综述基于系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。
结果
共筛选出 131 项研究，阅读了 96 篇摘要，纳入了 69 项研究。
讨论
在未来，循环 miRNAs 可以作为炎症性心脏病和脓毒症引起的心功能障碍背景下的诊断和疾病监测的生物标志物。考虑到不同动物模型的有希望的结果，某些 miRNAs 也可能在这种情况下作为新的治疗方法出现。
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