Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa (PI), Italy.
IRCSS Neuromed Mediterranean Neurological Institute, Via Atinense 18, 86077 Pozzilli (IS), Italy.
Int J Mol Sci. 2020 Dec 30;22(1):321. doi: 10.3390/ijms22010321.
Sepsis is a severe condition characterized by systemic inflammation. One of the most involved organs in sepsis is the heart. On the other hand, heart failure and dysfunction are some of the most leading causes of death in septic patients. miRNAs are short single-strand non-coding ribonucleic acids involved in the regulation of gene expression on a post-transcriptional phase, which means they are a part of the epigenetic process. Recently, researchers have found that miRNA expression in tissues and blood differs depending on different conditions. Because of this property, their use as serum sepsis biomarkers has also been explored. A narrative review is carried out to gather and summarize what is known about miRNAs' influence on cardiac dysfunction during sepsis. When reviewing the literature, we found at least 77 miRNAs involved in cardiac inflammation and dysfunction during sepsis. In the future, miRNAs may be used as early sepsis-induced cardiac dysfunction biomarkers or as new drug targets. This could help clinicians to early detect, prevent, and treat cardiac damage. The potential role of miRNAs as new diagnostic tools and therapeutic strategies worth deepening the complex network between non-coding RNA and biological pathways. Additional studies are needed to further investigate their role in sepsis-induced myocardium injury.
脓毒症是一种以全身炎症为特征的严重病症。在脓毒症中，最受影响的器官之一是心脏。另一方面，心力衰竭和功能障碍是导致脓毒症患者死亡的最主要原因之一。miRNA 是一种短的单链非编码核糖核酸，参与基因表达的转录后调控，这意味着它们是表观遗传过程的一部分。最近，研究人员发现，组织和血液中的 miRNA 表达因不同的情况而不同。由于这一特性，它们也被探索作为血清脓毒症生物标志物的用途。进行了一项叙述性综述，以收集和总结已知的关于 miRNA 在脓毒症期间对心脏功能障碍的影响。在回顾文献时，我们发现至少有 77 种 miRNA 参与了脓毒症期间的心脏炎症和功能障碍。在未来，miRNA 可能被用作早期脓毒症诱导的心脏功能障碍的生物标志物，或作为新的药物靶点。这可以帮助临床医生早期发现、预防和治疗心脏损伤。miRNA 作为新的诊断工具和治疗策略的潜在作用值得深入研究非编码 RNA 与生物途径之间的复杂网络。需要进一步的研究来进一步探讨它们在脓毒症引起的心肌损伤中的作用。
