Novikova A N, Mamedov L A, Egorova N D, Shekhter A B, Nikolaev A V
Biull Eksp Biol Med. 1988 Sep;106(9):355-8.
Hydroxyproline and ascorbic acid were measured in wound tissues and ascorbic acid was determined in the blood sera of 230 mature male Wistar rats with aseptic and infected surface wounds on days 1-10 (daily), 12, and 15. The principal morphologic characteristics of the granulation tissue were assessed by semiquantitative methods. An infected wound is characterized by increased hydroxyproline levels in the granulation tissue and elevated ascorbic acid concentration in the blood serum. The granulation tissue ascorbic acid level augments during the first nine days in case of an aseptic wound and during twelve days in case of an infected wound. Morphologic and biochemical correlations are indicative of a relationship between the ascorbic acid level on the one hand and granulation tissue vascularization and fibroblast proliferation on the other.
在第1至10天（每日）、第12天和第15天，对230只患有无菌性和感染性体表伤口的成年雄性Wistar大鼠的伤口组织进行羟脯氨酸和抗坏血酸测定，并对其血清中的抗坏血酸进行测定。通过半定量方法评估肉芽组织的主要形态学特征。感染伤口的特征是肉芽组织中羟脯氨酸水平升高以及血清中抗坏血酸浓度升高。无菌伤口情况下，肉芽组织抗坏血酸水平在头九天增加；感染伤口情况下，则在十二天内增加。形态学和生化相关性表明，一方面抗坏血酸水平与另一方面肉芽组织血管化和成纤维细胞增殖之间存在关联。
