Zakharov V V, Mamedov L A, Nikolaev A V, Gudz' T I, Kudriashov Iu B
Biull Eksp Biol Med. 1988 Jun;105(6):686-9.
Time-course changes in the specific activity of superoxide dismutase (SOD) and hydroperoxides were studied in granulation tissue and blood serum of 230 Wistar male rats weighing 200-210 g with simulated aseptic and infected surface wounds before and 1-10, 12, 15 days after the operation. Differences in the level range of SOD and hydroperoxides specific activity were demonstrated in tissues and sera. The dependence of hydroperoxide levels on the wound stage, as well as the dependence of SOD specific activity time-course on the character and severity of wound were stated. The allowances should be made of those differences in the shifts observed in anti- and pro-oxidative systems during wound healing when corrective therapeutic measures are considered.
在230只体重200 - 210克的雄性Wistar大鼠身上，模拟无菌和感染性体表伤口，研究了手术前以及术后1 - 10天、12天、15天肉芽组织和血清中超氧化物歧化酶（SOD）的比活性和氢过氧化物的时程变化。组织和血清中SOD和氢过氧化物比活性的水平范围存在差异。明确了氢过氧化物水平与伤口阶段的相关性，以及SOD比活性时程与伤口性质和严重程度的相关性。在考虑采取纠正性治疗措施时，应考虑到伤口愈合过程中抗氧化和促氧化系统变化的这些差异。
