Nikolaev A V, Mamedov L A, Zakharov V V, Belokrinitskiĭ D V, Kudriavitskiĭ A I
Biull Eksp Biol Med. 1988 Aug;106(8):224-7.
Main parameters of systemic immune reactivity were studied in 240 mature Wistar male rats with simulated aseptic and infected surface wounds before surgical intervention, and 1-10, 12 and 15 days after it. It was stated that aseptic wounds were responsible for nonspecific systemic response to the stress, whereas the presence of bacterial flora in the wound inhibited the development of humoral immune response in the presence of T-cell activation thus causing the dysfunction of the immune system and therefore affecting the course of wound progress. The consideration of all factors mentioned permits averting wound purulent complications in postsurgical period.
在240只成熟的雄性Wistar大鼠身上，研究了模拟无菌和感染性体表伤口在手术干预前、干预后1 - 10天、12天和15天的全身免疫反应主要参数。结果表明，无菌伤口会引发对应激的非特异性全身反应，而伤口中细菌菌群的存在，在T细胞激活的情况下会抑制体液免疫反应的发展，从而导致免疫系统功能障碍，进而影响伤口愈合进程。综合考虑上述所有因素，可避免术后伤口出现化脓性并发症。
