Taran Iu P, Nikolaev A V, Mamedov L A, Eliseeva S V, Zakharov V V
Biull Eksp Biol Med. 1988 May;105(5):552-4.
The variance of lipid peroxidation (LPO) was studied by the concentrations of malonic dialdehyde (MDA) in the tissue of wound bed and blood serum on the model of surface musculocutaneous aseptic and infected wounds simulated in 250 rats. The speed of oxygen consumption by isolated wound tissue was determined simultaneously. It was stated that the time course of MDA concentration in wounds and sera as well as tissue respiration in animals with infected wounds differed from those in animals with aseptic wounds. In a whole, MDA levels were found to be higher in cases with infected wounds and of changeable character. The latter animals demonstrated less intensive respiration of granulation tissue. Correlation between the variance of tissue respiration and MDA levels was established as was that of LPO and respiration with the phases of wound process. The findings could be used for the development of pathogenetic therapy and evaluation of its efficacy.
在250只大鼠模拟的体表肌皮无菌和感染伤口模型上，通过测定伤口床组织和血清中丙二醛（MDA）的浓度，研究脂质过氧化（LPO）的变化。同时测定分离的伤口组织的耗氧速度。结果表明，感染伤口动物伤口和血清中MDA浓度的时间进程以及组织呼吸与无菌伤口动物不同。总体而言，感染伤口病例中MDA水平较高且变化不定。后一组动物的肉芽组织呼吸强度较低。建立了组织呼吸变化与MDA水平之间的相关性，以及LPO和呼吸与伤口愈合阶段之间的相关性。这些发现可用于发病机制治疗的开发及其疗效评估。
