Department of Clinical Sciences, Lund University, Malmö, Sweden
Department of Clinical Sciences, Lund University, Malmö, Sweden.
Heart. 2020 May;106(9):691-697. doi: 10.1136/heartjnl-2019-315485. Epub 2019 Oct 31.
We recently identified a health conscious food pattern (HCFP) associated with reduced risk of cardiometabolic disease. However, the molecular events linking the healthy food pattern to reduced risk of cardiometabolic disease are unknown. Our aim was to identify plasma metabolites associated with the HCFP and test if such metabolites predict cardiometabolic disease and mortality.
Using liquid-chromatography mass-spectrometry, 112 plasma metabolites were measured in 3236 participants without cardiovascular disease (CVD) and diabetes mellitus from the population-based Malmö Diet and Cancer study. Metabolites associated with the HCFP were identified using multivariable adjusted linear regressions followed by Bonferroni correction. The healthy dietary biomarkers were subsequently related to risk of cardiometabolic disease and mortality during long-term follow-up with multivariable adjusted Cox proportional hazards models.
During a median follow-up time of 21.4 years, 603 participants developed CVD, 362 developed diabetes mellitus and 843 participants died. Five healthy dietary biomarkers were associated with the HCFP at baseline (p<0.0004) and four predicted at least one of the studied end points (p<0.05). Ergothioneine was the metabolite most strongly connected to the HCFP and was associated with a lower risk of coronary disease (HR per 1 SD increment of ergothioneine, HR=0.85, p=0.01), cardiovascular mortality (HR=0.79, p=0.002) and overall mortality (HR=0.86, p=4e-5).
We identified that higher ergothioneine was an independent marker of lower risk of cardiometabolic disease and mortality, which potentially can be induced by a specific healthy dietary intake.
我们最近确定了一种与降低心血管代谢疾病风险相关的健康意识食物模式（HCFP）。然而，将健康食物模式与降低心血管代谢疾病风险联系起来的分子事件尚不清楚。我们的目的是确定与 HCFP 相关的血浆代谢物，并检验这些代谢物是否可预测心血管代谢疾病和死亡率。
在无心血管疾病（CVD）和糖尿病的人群中，使用基于人群的马尔默饮食与癌症研究，对 3236 名参与者的 112 种血浆代谢物进行了液相色谱-质谱分析。使用多变量调整线性回归和 Bonferroni 校正，确定与 HCFP 相关的代谢物。在长期随访中，使用多变量调整的 Cox 比例风险模型，将健康饮食生物标志物与心血管代谢疾病和死亡率的风险相关联。
在中位随访时间为 21.4 年期间，603 名参与者发生了 CVD，362 名参与者发生了糖尿病，843 名参与者死亡。在基线时，有 5 种健康饮食生物标志物与 HCFP 相关（p<0.0004），有 4 种生物标志物预测了至少一个研究终点（p<0.05）。麦硫因是与 HCFP 相关性最强的代谢物，与冠心病风险降低相关（每增加 1 个标准差的麦硫因 HR，HR=0.85，p=0.01），与心血管死亡率（HR=0.79，p=0.002）和总死亡率（HR=0.86，p=4e-5）相关。
我们发现，较高的麦硫因是心血管代谢疾病和死亡率风险降低的独立标志物，这可能是由特定的健康饮食摄入引起的。
