Alavi Afsaneh, Shavit Eran, Archer Jeannine, Pagnoux Christian
Division of Dermatology, Department of Medicine, Women's College Hospital, University of Toronto, Toronto, ON, Canada.
York Dermatology Center, Richmond Hill, ON, Canada.
SAGE Open Med Case Rep. 2019 Oct 21;7:2050313X19882852. doi: 10.1177/2050313X19882852. eCollection 2019.
Hidradenitis suppurativa is a chronic inflammatory skin disease with dysregulation of the immune system. Its pathophysiology is not clear, and it has been reported in association with various inflammatory disorders such as pyoderma gangrenosum, arthritis, familial Mediterranean fever and inflammatory bowel diseases. However, the co-existence of HS and vasculitis is exceptional and has not been investigated. We report on five patients with vasculitis that are followed in our centers: one with Takayasu's arteritis, three with granulomatosis with polyangiitis and one with Behcet's disease and compare them with those previously reported in the literature. A case series and literature review with key words of "vasculitis," "hidradenitis suppurativa," and "acne inversa" found only one previous report of hidradenitis suppurativa and cutaneous vasculitis and two with Behcet's disease. Whereas the association of pyoderma gangrenosum and vasculitis is well-known, that with hidradenitis suppurativa is rarer. There may be some pathogenic continuum between hidradenitis suppurativa, pyoderma gangrenosum and vasculitis.
化脓性汗腺炎是一种免疫系统失调的慢性炎症性皮肤病。其病理生理学尚不清楚，且已报道它与多种炎症性疾病相关，如坏疽性脓皮病、关节炎、家族性地中海热和炎症性肠病。然而，化脓性汗腺炎与血管炎并存的情况极为罕见，尚未得到研究。我们报告了在我们中心随访的5例血管炎患者：1例患有大动脉炎，3例患有肉芽肿性多血管炎，1例患有白塞病，并将他们与文献中先前报道的病例进行比较。一项以“血管炎”、“化脓性汗腺炎”和“反向性痤疮”为关键词的病例系列和文献综述发现，先前仅有一篇关于化脓性汗腺炎与皮肤血管炎的报道，以及两篇关于白塞病的报道。虽然坏疽性脓皮病与血管炎的关联已为人熟知，但化脓性汗腺炎与血管炎的关联则较为罕见。化脓性汗腺炎、坏疽性脓皮病和血管炎之间可能存在一些致病连续性。
