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妊娠中期成功进行子宫肌瘤切除术。

Successful Myomectomy in the Second Trimester of Pregnancy.

作者信息

Allameh Zahra, Allameh Tajossadat

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Adv Biomed Res. 2019 Sep 30;8:60. doi: 10.4103/abr.abr_236_18. eCollection 2019.

DOI:10.4103/abr.abr_236_18
PMID:31673533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6796287/
Abstract

The prevalence of uterine myomas during pregnancy is estimated to be small. However, a significant fraction of these could lead to pregnancy complications. Myomectomy is rarely performed during pregnancy because of fear of miscarriage and the risk of uncontrolled hemorrhage necessitating hysterectomy. This article reports on a case of myomectomy of subserous leiomyoma that was causing septic necrosis, leukocytosis, rise of inflammatory markers (erythrocyte sedimentation rate and C-reactive protein), and pressure symptom on the liver. Myomectomy was performed at 20 weeks of gestation. The pregnancy continued with no further problems, and at 39 weeks and 1 day of gestation, vaginal delivery resulted in a healthy baby. It is postulated that when myomectomy is performed in carefully selected patients, it prevents sepsis due to myoma torsion and necrosis and also protects surrounding organs against damage.

摘要

据估计,孕期子宫肌瘤的患病率较低。然而,其中相当一部分可能导致妊娠并发症。由于担心流产以及存在因无法控制的出血而需要进行子宫切除术的风险,孕期很少进行肌瘤切除术。本文报道了一例浆膜下平滑肌瘤肌瘤切除术病例,该肌瘤导致了感染性坏死、白细胞增多、炎症标志物(红细胞沉降率和C反应蛋白)升高以及对肝脏的压迫症状。肌瘤切除术在妊娠20周时进行。妊娠继续进行且未出现进一步问题,在妊娠39周零1天时,经阴道分娩产下一名健康婴儿。据推测,在经过精心挑选的患者中进行肌瘤切除术时,可预防肌瘤扭转和坏死引起的败血症,并保护周围器官免受损害。

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1
Successful Myomectomy in the Second Trimester of Pregnancy.妊娠中期成功进行子宫肌瘤切除术。
Adv Biomed Res. 2019 Sep 30;8:60. doi: 10.4103/abr.abr_236_18. eCollection 2019.
2
Myomectomy during pregnancy: a feasible option.孕期子宫肌瘤切除术:一种可行的选择。
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First trimester myomectomy as an alternative to termination of pregnancy in a woman with a symptomatic uterine leiomyoma: a case report.孕早期子宫肌瘤剔除术作为有症状子宫平滑肌瘤女性终止妊娠的替代方案:一例病例报告
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Successful myomectomy in early pregnancy for a large asymptomatic uterine myoma: case report.早期妊娠时成功切除大型无症状子宫肌瘤:病例报告
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Myoma and myomectomy: Poor evidence concern in pregnancy.子宫肌瘤与子宫肌瘤切除术:妊娠相关证据不足
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Matern Fetal Med. 2023 Jul;5(3):199-202. doi: 10.1097/FM9.0000000000000193. Epub 2023 Jun 28.
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Unexpected early pregnancy during myomectomy followed by successful term delivery: A case report.子宫肌瘤切除术中意外早期妊娠并足月成功分娩:一例报告
Int J Reprod Biomed. 2024 Oct 14;22(8):673-678. doi: 10.18502/ijrm.v22i8.17242. eCollection 2024 Aug.
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Antenatal myomectomy of huge pedunculated fibroid.

本文引用的文献

1
Uterine Fibroid Torsion during Pregnancy: A Case of Laparotomic Myomectomy at 18 Weeks' Gestation with Systematic Review of the Literature.妊娠期间子宫肌瘤扭转:18周妊娠时剖腹子宫肌瘤切除术1例并文献系统综述
Case Rep Obstet Gynecol. 2017;2017:4970802. doi: 10.1155/2017/4970802. Epub 2017 Apr 24.
2
Successful myomectomy in early pregnancy for a large asymptomatic uterine myoma: case report.早期妊娠时成功切除大型无症状子宫肌瘤:病例报告
Pan Afr Med J. 2016 Jul 13;24:228. doi: 10.11604/pamj.2016.24.228.9890. eCollection 2016.
3
The management of uterine leiomyomas.
产前子宫肌瘤切除术治疗巨大带蒂肌瘤。
BMJ Case Rep. 2024 Jan 24;17(1):e257980. doi: 10.1136/bcr-2023-257980.
4
Use of point-of-care ultrasound to diagnose spontaneous rupture of fibroid in pregnancy.床旁超声在诊断妊娠合并子宫肌瘤自发性破裂中的应用。
POCUS J. 2021 Apr 22;6(1):16-21. doi: 10.24908/pocus.v6i1.14757. eCollection 2021.
子宫平滑肌瘤的管理
J Obstet Gynaecol Can. 2015 Feb;37(2):157-178. doi: 10.1016/S1701-2163(15)30338-8.
4
Laparotomic myomectomy in the 16th week of pregnancy: a case report.妊娠16周时的剖腹子宫肌瘤切除术:一例病例报告。
Case Rep Obstet Gynecol. 2014;2014:154347. doi: 10.1155/2014/154347. Epub 2014 Mar 4.
5
Management of uterine leiomyomas in pregnancy: review of literature.妊娠合并子宫肌瘤的处理:文献复习。
Updates Surg. 2013 Sep;65(3):179-82. doi: 10.1007/s13304-013-0198-z. Epub 2013 Jan 30.
6
Caesarean Myomectomy: Feasibility and safety.剖宫产子宫肌瘤切除术:可行性与安全性
Sultan Qaboos Univ Med J. 2012 May;12(2):190-6. Epub 2012 Apr 9.
7
[Myoma and pregnancy: when medical treatment is not sufficient].[子宫肌瘤与妊娠:当药物治疗不足时]
J Gynecol Obstet Biol Reprod (Paris). 2012 May;41(3):307-10. doi: 10.1016/j.jgyn.2011.10.002. Epub 2011 Nov 15.
8
Surgical treatment of large smooth muscle tumor of uncertain malignant potential during pregnancy.孕期潜在恶性不明的大平滑肌肿瘤的手术治疗
Med Glas (Zenica). 2011 Aug;8(2):290-2.
9
Hemoperitoneum caused by a bleeding myoma in pregnancy.妊娠期子宫肌瘤出血导致的腹腔积血。
Acta Clin Croat. 2010 Jun;49(2):197-200.
10
Pregnancy-preserving myomectomy: preliminary report on a new surgical technique.保留妊娠的子宫肌瘤切除术:一种新手术技术的初步报告。
Eur J Contracept Reprod Health Care. 2008 Sep;13(3):323-6. doi: 10.1080/13625180802075281.