Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, China.
J Cell Biochem. 2020 Mar;121(3):2058-2063. doi: 10.1002/jcb.29492. Epub 2019 Oct 31.
tRNA-derived small RNAs (tRFs), a kind of noncoding RNAs, are generated from transfer RNAs. tRFs have some types according to their source and sizes. They play important roles in cell life and carcinogenesis. In this paper, we review the biogenesis and biological properties. We also focus on current progress of tRFs and some tsRNAs such as tRF-Leu-CAG, which have been studied or will be further investigated in tumorgenesis and diagnostic biomarkers in the clinic.
tRNA 衍生的小 RNA（tRFs）是一类非编码 RNA，来源于转移 RNA。tRFs 根据其来源和大小有一些类型。它们在细胞生命和癌变中发挥重要作用。本文综述了 tRFs 的生物发生和生物学特性。我们还重点介绍了 tRFs 及一些 tsRNAs 的最新进展，如 tRF-Leu-CAG，它们在肿瘤发生和临床诊断生物标志物方面已经得到或将要进一步研究。
