Department of Pediatrics, New York University School of Medicine, New York, NY, USA; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA; Department of Population Health, New York University School of Medicine, New York, NY, USA; NYU Wagner School of Public Service, New York, NY, USA; NYU College of Global Public Health, New York, NY, USA.
Department of Population Health, New York University School of Medicine, New York, NY, USA.
Environ Pollut. 2020 Jan;256:113334. doi: 10.1016/j.envpol.2019.113334. Epub 2019 Oct 23.
The goal of this study was to assess biomarkers of exposure to glyphosate and assess potential associations with renal function in children. Glyphosate is used ubiquitously in agriculture worldwide. While previous studies have indicated that glyphosate may have nephrotoxic effects, few have examined potential effects on kidney function in children. We leveraged three cohorts across different phases of child development and measured urinary levels of glyphosate. We evaluated associations of glyphosate with three biomarkers of kidney injury: albuminuria (ACR), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury marker 1 (KIM-1). Multivariable regression analyses examined associations of glyphosate with kidney injury biomarkers controlling for covariates. We identified glyphosate in 11.1% of the total participants. The herbicide was detected more frequently in the neonate population (30%). Multivariable regression models failed to identify significant associations of log-transformed glyphosate with any of the kidney injury biomarkers, controlling for covariates age, sex, and maternal education. While we confirm detectability of glyphosate in children's urine at various ages and stages of life, there is no evidence in this study for renal injury in children exposed to low levels of glyphosate. Further studies of larger sample size are indicated to better understand putative deleterious effects of the herbicide after different levels of exposure.
本研究旨在评估暴露于草甘膦的生物标志物，并评估其与儿童肾功能的潜在关联。草甘膦在全球农业中广泛使用。虽然先前的研究表明草甘膦可能具有肾毒性作用，但很少有研究检查其对儿童肾功能的潜在影响。我们利用三个处于不同儿童发育阶段的队列，测量了尿样中的草甘膦水平。我们评估了草甘膦与三种肾损伤生物标志物的关联：蛋白尿（ACR）、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和肾损伤标志物 1（KIM-1）。多变量回归分析控制协变量后，研究了草甘膦与肾损伤生物标志物的关联。我们在 11.1%的总参与者中发现了草甘膦。除草剂在新生儿人群中（30%）的检出率更高。多变量回归模型未发现草甘膦与任何肾损伤生物标志物之间存在显著关联，控制了年龄、性别和母亲教育等协变量。虽然我们证实了在儿童尿液中检测到不同年龄和生命阶段的草甘膦，但本研究并未发现接触低水平草甘膦的儿童存在肾损伤的证据。需要更大样本量的进一步研究，以更好地了解在不同暴露水平后除草剂可能产生的有害影响。
