Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, Jiangsu, 215123, PR China; Department of Social medicine, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, 215123, PR China.
School of Nursing, Medical College of Soochow University, Suzhou, Jiangsu, 215123, PR China.
Ageing Res Rev. 2019 Dec;56:100965. doi: 10.1016/j.arr.2019.100965. Epub 2019 Oct 31.
Dementia represents one of the most common neurodegenerative disorders in older adults. However, it is still unclear whether non-pharmacological therapies (NPTs) are effective or not and which treatment should be preferred. We applied a series of search strategies to identify eligible randomized controlled trials on 1st October, 2018, investigating the effects of NPTs of dementia in the older persons. Pairwise and network meta-analyses were sequentially performed. A total of 31 trials were included, which enrolled 1895 participants and 7 NPTs. Compared with control group, all the NPTs included were statistically beneficial to cognitive function, and our study indicated Comprehensive Therapy(CT) [the surface under the cumulative ranking curve (SUCRA = 92.42%)] might be the best choice for dementia patients. Our study suggests CT might be the optimal NPT for improving the cognitive function of dementia patients. However, the above conclusions need to be further analyzed.
痴呆症是老年人最常见的神经退行性疾病之一。然而，目前仍不清楚非药物治疗（NPT）是否有效，以及应该首选哪种治疗方法。我们于 2018 年 10 月 1 日应用了一系列搜索策略来确定合格的随机对照试验，以研究非药物治疗对老年人痴呆症的影响。我们依次进行了成对和网络荟萃分析。共有 31 项试验纳入了 1895 名参与者和 7 种 NPT。与对照组相比，纳入的所有 NPT 在认知功能方面均具有统计学意义上的益处，我们的研究表明综合治疗（CT）[累积排序曲线下面积（SUCRA = 92.42%）]可能是痴呆症患者的最佳选择。我们的研究表明 CT 可能是改善痴呆症患者认知功能的最佳 NPT。然而，上述结论需要进一步分析。
