Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
J Formos Med Assoc. 2020 Apr;119(4):813-820. doi: 10.1016/j.jfma.2019.10.013. Epub 2019 Nov 1.
BACKGROUND/PURPOSE: Burning mouth syndrome (BMS) is characterized by burning sensation of the oral mucosa in the absence of clinically apparent oral mucosal alterations. This study evaluated the anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity in 884 BMS patients.
The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, GPCA levels in 884 BMS patients were measured and compared with the corresponding levels in 442 age- and sex-matched healthy control subjects.
We found that 175 (19.8%), 143 (16.2%), 42 (4.8%), 20 (2.3%), 170 (19.2%), and 109 (12.3%) BMS patients had blood Hb, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 884 BMS patients had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 442 healthy control subjects (all P-values < 0.005). Of 175 anemic BMS patients, 95 had normocytic anemia, 27 had thalassemia trait-induced anemia, 21 had iron deficiency anemia, 15 had pernicious anemia, 15 had macrocytic anemia other than pernicious anemia, and 2 had microcytic anemia other than iron deficiency anemia and thalassemia trait-induced anemia. Burning sensation of oral mucosa (100.0%), dry mouth (48.1%), numbness of oral mucosa (30.7%), and dysfunction of taste (16.7%) were the four common symptoms in 884 BMS patients.
BMS patients have significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects.
背景/目的：灼口综合征（BMS）的特征为口腔黏膜烧灼感，而无明显的临床可见的口腔黏膜改变。本研究评估了 884 例 BMS 患者的贫血、血液营养素缺乏、高同型半胱氨酸血症和血清壁细胞抗体（GPCA）阳性。
测量 884 例 BMS 患者的血液血红蛋白（Hb）和血清铁、维生素 B12、叶酸、同型半胱氨酸、GPCA 水平，并与 442 例年龄和性别匹配的健康对照者的相应水平进行比较。
我们发现 175 例（19.8%）、143 例（16.2%）、42 例（4.8%）、20 例（2.3%）、170 例（19.2%）和 109 例（12.3%）BMS 患者分别有血液 Hb、血清铁、维生素 B12 和叶酸缺乏、高同型半胱氨酸血症和血清 GPCA 阳性。此外，884 例 BMS 患者的血液 Hb 和血清铁、维生素 B12 和叶酸缺乏、高同型半胱氨酸血症和血清 GPCA 阳性频率显著高于 442 例健康对照者（所有 P 值均<0.005）。在 175 例贫血的 BMS 患者中，95 例为正细胞性贫血，27 例为地中海贫血所致贫血，21 例为缺铁性贫血，15 例为恶性贫血，15 例为巨幼细胞性贫血而非恶性贫血，2 例为小细胞性贫血而非缺铁性贫血和地中海贫血所致贫血。884 例 BMS 患者的四种常见症状为口腔黏膜烧灼感（100.0%）、口干（48.1%）、口腔黏膜麻木（30.7%）和味觉障碍（16.7%）。
BMS 患者的血液 Hb 和血清铁、维生素 B12 和叶酸缺乏、高同型半胱氨酸血症和血清 GPCA 阳性频率显著高于健康对照者。
