Shimojo N, Hirai M, Naka K, Yoshikawa C, Okuda K, Aono S, Isshiki G, Fujii S
Department of Laboratory Medicine, Osaka City University Medical School, Japan.
Clin Chim Acta. 1988 Aug 15;176(1):101-6. doi: 10.1016/0009-8981(88)90179-9.
Plasma concentrations of fructosamine, an indicator of glycated plasma proteins, were measured in non-diabetic children and children with insulin-dependent diabetes mellitus (IDDM) to see if they also correlate with glycemic control in children as well as in adults. Non-diabetic children aged less than 4 yr had significantly lower plasma fructosamine than non-diabetic children aged 4 or more. Total plasma protein in these children was slightly lower or close to that of older children. There was no difference in fructosamine between non-diabetic children aged 4 or more and healthy adult subjects. Plasma fructosamine in children with IDDM was twofold that of age-matched controls. In children with IDDM, correlations between fructosamine and HbAI (r = 0.799) or HbAIc (r = 0.841) were high. The measurement of plasma fructosamine, which is practical in children because of the small sample volume needed and no influence of HbF, is useful in the management of children with IDDM.
测量了非糖尿病儿童和胰岛素依赖型糖尿病（IDDM）儿童血浆中糖化血浆蛋白的指标——果糖胺的浓度，以观察其是否也与儿童及成人的血糖控制相关。年龄小于4岁的非糖尿病儿童血浆果糖胺水平显著低于4岁及以上的非糖尿病儿童。这些儿童的总血浆蛋白略低于或接近年龄较大儿童。4岁及以上的非糖尿病儿童与健康成人受试者的果糖胺水平无差异。IDDM儿童的血浆果糖胺是年龄匹配对照组的两倍。在IDDM儿童中，果糖胺与糖化血红蛋白A1（r = 0.799）或糖化血红蛋白A1c（r = 0.841）之间的相关性很高。由于所需样本量小且不受胎儿血红蛋白（HbF）影响，血浆果糖胺的测量在儿童中切实可行，对IDDM儿童的管理很有用。
