Biotechnology & Food Engineering Department, Technion, Israel Institute of Technology, Haifa 3200003, Israel.
Biotechnology & Food Engineering Department, Technion, Israel Institute of Technology, Haifa 3200003, Israel.
Adv Colloid Interface Sci. 2019 Dec;274:102038. doi: 10.1016/j.cis.2019.102038. Epub 2019 Oct 18.
The post genomic era has brought breakthroughs in our understanding of the complex and fascinating symbiosis we have with our co-evolving microbiota, and its dramatic impact on our physiology, physical and mental health, mood, interpersonal communication, and more. This fast "proliferating" knowledge, particularly related to the gut microbiota, is leading to the development of numerous technologies aimed to promote our health via prudent modulation of our gut microbiota. This review embarks on a journey through the gastrointestinal tract from a biomaterial science and engineering perspective, and focusses on the various state-of-the-art approaches proposed in research institutes and those already used in various industries and clinics, for delivery to the gut microbiota, with emphasis on the latest developments published within the last 5 years. Current and possible future trends are discussed. It seems that future development will progress toward more personalized solutions, combining high throughput diagnostic omic methods, and precision interventions.
后基因组时代，我们对共生微生物的复杂而迷人的共生关系有了突破性的理解，其对我们的生理、身心健康、情绪、人际交流等方面都产生了巨大影响。这些快速“繁衍”的知识，特别是与肠道微生物组相关的知识，正促使许多技术的发展，旨在通过谨慎调节肠道微生物组来促进我们的健康。
从生物材料科学和工程的角度来看，本篇综述将沿着胃肠道进行探索，重点介绍研究机构提出的各种最新方法以及各行业和临床实践中已经使用的方法，以将其递送到肠道微生物组，特别强调过去 5 年发表的最新进展。目前和未来可能的趋势也进行了讨论。未来的发展似乎将朝着更加个性化的解决方案方向发展，结合高通量诊断组学方法和精准干预措施。
