Bonadio W A, Wagner V
Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee 53233.
Clin Pediatr (Phila). 1988 Oct;27(10):495-8. doi: 10.1177/000992288802701006.
A prospective evaluation of 75 consecutive children with lacerations of the face, lip, and scalp who received TAC (tetracaine, epinephrine [adrenalin], cocaine) topical anesthetic for the repair of their wound was performed. The TAC preparation contained one-half the conventional concentration of cocaine (5.9%) and tetracaine (0.25%) previously used in other studies that have evaluated its anesthetic efficacy. A maximal dosage of 3 ml of TAC (containing 175 mg cocaine and 7.5 mg tetracaine) was applied to each laceration. The diluted TAC preparation provided complete anesthesia for approximately 95% of the more than 400 sutures placed. No adverse reactions were noted in any patient who received TAC, and in no instance did a complication of wound healing occur. The original formulation of TAC was arbitrarily composed, and the maximum concentration per dosage of the potentially toxic component medications of TAC that can be "safely" applied to dermal lacerations in children remains to be defined. Utilization of this diluted preparation will diminish the risk of potential systemic toxicity from the absorbed component medications of TAC without compromising anesthetic efficacy.
对75例连续的面部、唇部和头皮裂伤儿童进行了前瞻性评估，这些儿童在伤口修复时接受了丁卡因、肾上腺素、可卡因（TAC）局部麻醉。TAC制剂中可卡因（5.9%）和丁卡因（0.25%）的浓度为其他评估其麻醉效果的研究中所使用的传统浓度的一半。每处裂伤使用的TAC最大剂量为3 ml（含175 mg可卡因和7.5 mg丁卡因）。稀释后的TAC制剂为400余针缝合中的约95%提供了完全麻醉。接受TAC的任何患者均未出现不良反应，伤口愈合也未出现并发症。TAC的原始配方是随意配制的，TAC中可“安全”应用于儿童皮肤裂伤的潜在有毒成分药物的每剂量最大浓度仍有待确定。使用这种稀释制剂将降低TAC吸收成分药物潜在全身毒性的风险，同时不影响麻醉效果。
