Smith S M, Barry R C
Department of Clinical Pediatrics, UMDNJ-Robert Wood Johnson Medical School.
Pediatr Emerg Care. 1990 Dec;6(4):266-70. doi: 10.1097/00006565-199012000-00004.
A randomized, prospective, double-blind study comparing three formulations of the topical anesthetic solution TAC for laceration repair was undertaken in 250 children. The children's wounds were anesthetized with either TAC I (original formulation--0.5% tetracaine, 1:2000 Adrenalin, 11.8% cocaine), TAC II (1.0% tetracaine, 1:4000 Adrenalin, 7.0% cocaine), or TAC III (1.0% tetracaine, 1:4000 Adrenalin, 4.0% cocaine) prior to repair. The solutions were compared with respect to efficacy, acceptability, wound complications, and side effects. We found comparable efficacy of the three formulations, with similar efficacy to 1% lidocaine infiltration for facial and scalp wounds. Anesthesia for extremity wounds was adequate in only 39.9% of cases, regardless of TAC strength. Wound complications and side effects were within expected and acceptable limits. Our findings support use of TAC for face and scalp lacerations and a change to a less concentrated TAC preparation, such as our "TAC III," which is presumably safer for widespread use.
对250名儿童进行了一项随机、前瞻性、双盲研究，比较三种用于伤口缝合的外用麻醉溶液TAC配方。在伤口缝合前，用TAC I（原始配方——0.5%丁卡因、1:2000肾上腺素、11.8%可卡因）、TAC II（1.0%丁卡因、1:4000肾上腺素、7.0%可卡因）或TAC III（1.0%丁卡因、1:4000肾上腺素、4.0%可卡因）对儿童伤口进行麻醉。比较了这三种溶液在疗效、可接受性、伤口并发症和副作用方面的情况。我们发现三种配方的疗效相当，对于面部和头皮伤口，其疗效与1%利多卡因浸润相似。无论TAC浓度如何，仅39.9%的四肢伤口麻醉效果良好。伤口并发症和副作用在预期和可接受范围内。我们的研究结果支持将TAC用于面部和头皮裂伤，并改用浓度较低的TAC制剂，如我们的“TAC III”，据推测这种制剂更安全，可广泛使用。
