含丁香精油的电纺聚己内酯/明胶纳米纤维垫用于抗菌伤口敷料的评估。
Evaluation of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Mats Containing Clove Essential Oil for Antibacterial Wound Dressing.
作者信息
Unalan Irem, Endlein Stefan J, Slavik Benedikt, Buettner Andrea, Goldmann Wolfgang H, Detsch Rainer, Boccaccini Aldo R
机构信息
Institute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander-University Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany.
Chair of Aroma and Smell Research, Department of Chemistry and Pharmacy, Friedrich-Alexander-University Erlangen-Nuremberg, Henkestraße 9, 91054 Erlangen, Germany.
出版信息
Pharmaceutics. 2019 Nov 1;11(11):570. doi: 10.3390/pharmaceutics11110570.
The objective of this study was to produce antibacterial poly(ε-caprolactone) (PCL)-gelatin (GEL) electrospun nanofiber mats containing clove essential oil (CLV) using glacial acetic acid (GAA) as a "benign" (non-toxic) solvent. The addition of CLV increased the fiber diameter from 241 ± 96 to 305 ± 82 nm. Aside from this, the wettability of PCL-GEL nanofiber mats was increased by the addition of CLV. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the presence of CLV, and the actual content of CLV was determined by gas chromatography-mass spectrometry (GC-MS). Our investigations showed that CLV-loaded PCL-GEL nanofiber mats did not have cytotoxic effects on normal human dermal fibroblast (NHDF) cells. On the other hand, the fibers exhibited antibacterial activity against and Consequently, PCL-GEL/CLV nanofiber mats are potential candidates for antibiotic-free wound healing applications.
本研究的目的是使用冰醋酸（GAA）作为“良性”（无毒）溶剂，制备含有丁香精油（CLV）的抗菌聚（ε-己内酯）（PCL）-明胶（GEL）电纺纳米纤维垫。CLV的添加使纤维直径从241±96纳米增加到305±82纳米。除此之外，CLV的添加提高了PCL-GEL纳米纤维垫的润湿性。傅里叶变换红外光谱（FTIR）分析证实了CLV的存在，并且通过气相色谱-质谱联用（GC-MS）测定了CLV的实际含量。我们的研究表明，负载CLV的PCL-GEL纳米纤维垫对正常人皮肤成纤维细胞（NHDF）没有细胞毒性作用。另一方面，这些纤维对[具体细菌名称1]和[具体细菌名称2]表现出抗菌活性。因此，PCL-GEL/CLV纳米纤维垫是无抗生素伤口愈合应用的潜在候选材料。
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