Akturk Aysen
Department of Chemical Engineering, Istanbul Technical University, Istanbul34469, Turkey.
ACS Omega. 2023 Feb 1;8(6):5553-5560. doi: 10.1021/acsomega.2c06881. eCollection 2023 Feb 14.
The use of biocompatible materials and fabrication methods is of particular importance in the development of wound dressings. Cellulose acetate (CA) has excellent properties for wound dressing applications, but it is insufficient for the wound healing process due to its lack of bioactive and antibacterial properties. In this study, CA was electrospun with retinyl palmitate (RP) and clove essential oil (CLV) to fabricate a novel antibacterial and antioxidant biomaterial. The effects of RP and CLV incorporation on the surface morphology, fiber diameter, antioxidant activity, antibacterial activity, cell viability, and release behavior of the fabricated CA mats were investigated. In light of these studies, it was determined that the nanofiber mat, fabricated with a 15% w/v CA polymer concentration, a 1% w/w RP ratio, and a 5% w/w CLV ratio, was biocompatible with L929 fibroblast cells with antibacterial and antioxidant properties. Overall, results showed that this nanofiber offers promise for use as a wound dressing.
在伤口敷料的开发中，使用生物相容性材料和制造方法尤为重要。醋酸纤维素（CA）在伤口敷料应用方面具有优异的性能，但由于缺乏生物活性和抗菌性能，对于伤口愈合过程来说是不够的。在本研究中，将醋酸纤维素与棕榈酸视黄酯（RP）和丁香精油（CLV）进行电纺丝，以制备一种新型的抗菌和抗氧化生物材料。研究了RP和CLV的加入对所制备的CA垫的表面形态、纤维直径、抗氧化活性、抗菌活性、细胞活力和释放行为的影响。根据这些研究，确定了以15% w/v的CA聚合物浓度、1% w/w的RP比例和5% w/w的CLV比例制备的纳米纤维垫与L929成纤维细胞具有生物相容性，并具有抗菌和抗氧化性能。总体而言，结果表明这种纳米纤维有望用作伤口敷料。
