Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, South Africa.
Department of Pharmacy and Pharmacology, Rhodes University, Grahamstown, South Africa.
Arch Physiol Biochem. 2022 Apr;128(2):306-312. doi: 10.1080/13813455.2019.1680697. Epub 2019 Nov 5.
Pentacyclic triterpenes (such as maslinic acid) are natural anti-diabetic agents that ameliorate glucose metabolism in diet-induced prediabetes. However, the effects of bredemolic acid (BA), maslinic acid isomer, is yet unknown in prediabetic (PD) conditions.
To investigate the effects of BA on some glucose homeostasis parameters in high-fat high-carbohydrate (HFHC) diet-induced PD rats.
Thirty-six (36) male rats (150-180 g) were divided into two groups, the normal diet (ND) non-prediabetic, NPD ( = 6) and the HFHC diet PD groups ( = 30). The PD animals were further sub-divided into five groups ( = 6) where they were treated with BA for 12 weeks while monitoring changes in blood glucose, caloric intake, and body weight.
Diet-induced prediabetes resulted in increased body weight, caloric intake, glycated haemoglobin, and glucose tolerance. BA treatment ameliorated glucose tolerance, lowered plasma insulin and increased expression of glucose transporter 4 (GLUT 4) in rats.
BA administration restored glucose homeostasis in diet-induced prediabetes regardless of diet intervention.
五环三萜（如齐墩果酸）是天然的抗糖尿病药物，可改善饮食诱导的糖尿病前期的葡萄糖代谢。然而，倍半萜酸（BA），齐墩果酸的异构体，在糖尿病前期（PD）条件下的作用尚不清楚。
研究倍半萜酸（BA）对高脂肪高碳水化合物（HFHC）饮食诱导的糖尿病前期大鼠某些葡萄糖稳态参数的影响。
将 36 只（36）只雄性大鼠（150-180g）分为两组，正常饮食（ND）非糖尿病组（NPD，=6）和高脂肪高碳水化合物饮食（HFHC）糖尿病前期组（PD，=30）。PD 动物进一步分为五组（=6），其中 12 周内用 BA 处理，监测血糖、热量摄入和体重的变化。
饮食诱导的糖尿病前期导致体重、热量摄入、糖化血红蛋白和葡萄糖耐量增加。BA 治疗改善了葡萄糖耐量，降低了血浆胰岛素水平，并增加了大鼠葡萄糖转运蛋白 4（GLUT4）的表达。
BA 给药恢复了饮食诱导的糖尿病前期的葡萄糖稳态，而与饮食干预无关。
