Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South Africa.
Department of Pharmacy and Pharmacology, Rhodes University, Grahamstown, South Africa.
Can J Gastroenterol Hepatol. 2020 Feb 20;2020:2475301. doi: 10.1155/2020/2475301. eCollection 2020.
Prediabetes is an intermediary hyperglycaemic state that precedes type 2 diabetes mellitus (T2DM) in which abnormal metabolism of glucose and lipids occurs in organs such as the liver. Evidence has shown that, about 70% of T2DM patients develop hepatic dysfunction which is found to begin during the prediabetic stage. Bredemolic acid, a pentacyclic triterpene, has been found to improve insulin sensitivity in diet-induced prediabetic rats. The effects of this compound on liver function, however, are unknown. This study was therefore designed to investigate the effects of BA on liver function in high fat-high carbohydrate (HFHC) diet-induced prediabetic rats.
Thirty-six (36) male rats that weigh 150 g-180 g were divided into two groups, the non-prediabetic ( = 6) and the prediabetic groups ( = 6) and the prediabetic groups ( = 6) and the prediabetic groups (.
The induction of prediabetes resulted in increased release of liver enzymes (AST and ALT), increased liver glycogen and triglyceride, lipid peroxidation, and decreased sterol regulatory element-binding protein (SREBP1c) and antioxidant enzymes. However, the administration of BA decreased liver enzyme concentrations, decreased hepatic oxidative stress, and improved antioxidant enzymes such as SOD and GPx.
BA administration improved liver function in diet-induced prediabetic rats in the presence or absence of dietary intervention.
糖尿病前期是一种中间高血糖状态，发生于 2 型糖尿病（T2DM）之前，此时葡萄糖和脂质在肝脏等器官的代谢发生异常。有证据表明，大约 70%的 T2DM 患者会出现肝功能障碍，而这种障碍在糖尿病前期就已经开始出现。 Bredemolic 酸是一种五环三萜，已被发现可改善饮食诱导的糖尿病前期大鼠的胰岛素敏感性。然而，该化合物对肝功能的影响尚不清楚。因此，本研究旨在探讨 BA 对高脂肪高碳水化合物（HFHC）饮食诱导的糖尿病前期大鼠肝功能的影响。
将 36 只体重为 150-180g 的雄性大鼠分为两组，非糖尿病组（n=6）和糖尿病前期组（n=6），糖尿病前期组又分为（n=6）。
糖尿病前期的诱导导致肝脏酶（AST 和 ALT）释放增加、肝糖原和甘油三酯增加、脂质过氧化、固醇调节元件结合蛋白 1c（SREBP1c）和抗氧化酶减少。然而，BA 的给药降低了肝酶浓度，降低了肝氧化应激，并改善了 SOD 和 GPx 等抗氧化酶。
BA 给药可改善饮食诱导的糖尿病前期大鼠的肝功能，无论是否进行饮食干预。
