最小表面修饰的胶体 - 金纳米棱柱体和纳米棒 - 的生物分布和长期命运的比较。
comparison of the biodistribution and long-term fate of colloids - gold nanoprisms and nanorods - with minimum surface modification.
机构信息
Department of Instrument Science & Engineering, School of Electronic Information & Electrical Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis & Treatment Instrument, Institute of Nano Biomedicine & Engineering, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai 200240, China.
Instituto de Ciencia de Materiales de Aragón (ICMA), CSIC/Universidad de Zaragoza, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain.
出版信息
Nanomedicine (Lond). 2019 Dec;14(23):3035-3055. doi: 10.2217/nnm-2019-0253. Epub 2019 Nov 5.
To study the difference in biodistribution of gold nanoprisms (NPr) and nanorods (NR), PEGylated to ensure colloidal stability. Surface changes were studied for nanoparticles in different media, while the biodistribution was quantified and imaged . Upon interaction with the mouse serum, NR showed more abrupt changes in surface properties than NPr. In the tests, while NPr accumulated similarly in the spleen and liver, NR showed much higher gold presence in the spleen than in liver; together with some accumulation in kidneys, which was nonexistent in NPr. NPr were cleared from the tissues 2 months after administration, while NR were more persistent. The results suggest that the differential biodistribution is caused by size-/shape-dependent interactions with the serum.
为了研究金纳米棒（NR）和金纳米棱柱（NPr）的生物分布差异，我们对其进行了聚乙二醇（PEG）修饰以确保胶体稳定性。我们研究了纳米颗粒在不同介质中的表面变化，同时对其生物分布进行了定量和成像。当与小鼠血清相互作用时，NR 的表面性质变化比 NPr 更为突然。在实验中，NPr 在脾脏和肝脏中的积累相似，而 NR 在脾脏中的金含量明显高于肝脏；同时还在肾脏中有所积累，而 NPr 则没有。NPr 在给药后 2 个月从组织中清除，而 NR 则更为持久。结果表明，这种差异的生物分布是由与血清的大小/形状依赖性相互作用引起的。
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