金纳米粒子的几何形状和表面特性会影响其在巨噬细胞中的生物分布和摄取。
Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages.
机构信息
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84108, USA.
出版信息
Eur J Pharm Biopharm. 2011 Apr;77(3):417-23. doi: 10.1016/j.ejpb.2010.11.010. Epub 2010 Nov 18.
Abstract
Spherical and rod-shaped gold nanoparticles with surface poly(ethylene glycol) (PEG) chains were characterized for size, shape, charge, poly dispersity and surface plasmon resonance. The nanoparticles were injected intravenously to 6-8-week-old female nu/nu mice bearing orthotopic ovarian tumors, and their biodistribution in vital organs was compared. Gold nanorods were taken up to a lesser extent by the liver, had longer circulation time in the blood, and higher accumulation in the tumors, compared with their spherical counterparts. The cellular uptake of PEGylated gold nanoparticles by a murine macrophage-like cell line as a function of geometry was examined. Compared to nanospheres, PEGylated gold nanorods were taken up to a lesser extent by macrophages. These studies point to the importance of gold nanoparticle geometry and surface properties on transport across biological barriers.
摘要
球形和棒状的金纳米粒子具有表面聚乙二醇（PEG）链，其大小、形状、电荷、多分散性和表面等离子体共振都得到了表征。将纳米粒子静脉注射到 6-8 周龄的携带原位卵巢肿瘤的雌性无胸腺裸鼠体内，并比较其在重要器官中的分布。与球形纳米粒子相比，金纳米棒在肝脏中的摄取量较小，在血液中的循环时间更长，在肿瘤中的积累量更高。作为几何形状的函数，考察了聚乙二醇化金纳米粒子被鼠源巨噬细胞样细胞系摄取的情况。与纳米球相比，聚乙二醇化金纳米棒被巨噬细胞摄取的量较少。这些研究表明，金纳米粒子的几何形状和表面性质对穿过生物屏障的转运很重要。
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