Ariel Hannah, Cooke John P
HOUSTON METHODIST RESEARCH INSTITUTE, HOUSTON METHODIST HOSPITAL, HOUSTON, TEXAS.
Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):214-219. doi: 10.14797/mdcj-15-3-214.
Proton pump inhibitors (PPIs) are effective agents for the treatment of gastroesophageal reflux (GERD). However, these drugs have not been approved for long-term use. Now sold over the counter, these agents are being used chronically for GERD without medical supervision. The long-term use of PPIs may have significant adverse effects, in part mediated by their effect of accelerating vascular aging. Physicians should assist patients in tapering off their use of PPIs and replacing them with lifestyle modifications and/or other agents that have better long-term safety profiles.
质子泵抑制剂（PPIs）是治疗胃食管反流病（GERD）的有效药物。然而，这些药物尚未被批准用于长期使用。现在这些药物可在柜台购买，正被患者在无医学监督的情况下长期用于治疗GERD。长期使用PPIs可能会产生重大不良反应，部分是由其加速血管老化的作用介导的。医生应协助患者逐渐减少PPIs的使用，并代之以生活方式的改变和/或其他具有更好长期安全性的药物。
