Amit Arora, Gaurav Kapoor, Vikas Ambiya, Ashok Kumar, Harpreet A Singh, Shivani Arora
Base Hospital Delhi Cantt-110010, India.
Army College of Medical Sciences, Delhi Cantt, India.
Rom J Ophthalmol. 2019 Jul-Sep;63(3):217-221.
At high altitude changes in corneal thickness and intraocular pressure (IOP) has been a subject of investigation for decades. The mechanism of action of these changes is still unknown. Extensive research is carried out to know effect of hypoxia on humans at high altitude. Corneal thickness and intraocular pressure are important parameter in ophthalmology with both diagnostic and therapeutic implications. We studied the corneal thickness and intraocular pressure in highlanders and compared the same with lowlanders. This observational study included two groups, each consisting of 500 individuals residing at high altitude (more than 10,000 ft above sea level). Three measurements of intraocular pressure of both eyes in each group were noted with Goldmann applanation tonometer and mean of the three readings was taken. Central Corneal Thickness (CCT) was measured by ultra sound pachymetry. The parameters of two groups were compared statistically. There was a statistically significant difference between corneal thicknesses of the two groups studied, however no overall statistically significant difference in intraocular pressure of both these groups was found. The highlanders have a thinner cornea as compared to lowlanders. The IOP is significantly higher in the highlander males as compared to lowlander males. However, the mean IOP is comparable between the overall population of the high altitude and that of low altitude.
几十年来，高海拔地区角膜厚度和眼压的变化一直是研究的课题。这些变化的作用机制仍然未知。人们进行了广泛的研究以了解缺氧对高海拔地区人类的影响。角膜厚度和眼压是眼科的重要参数，具有诊断和治疗意义。我们研究了高原居民的角膜厚度和眼压，并将其与低地居民进行了比较。这项观察性研究包括两组，每组由500名居住在高海拔地区（海拔超过10000英尺）的个体组成。使用戈德曼压平眼压计记录每组中每只眼睛的三次眼压测量值，并取三次读数的平均值。通过超声测厚法测量中央角膜厚度（CCT）。对两组的参数进行统计学比较。研究的两组之间角膜厚度存在统计学上的显著差异，然而，这两组的眼压总体上没有统计学上的显著差异。与低地居民相比，高原居民的角膜更薄。与低地男性相比，高原男性的眼压明显更高。然而，高海拔地区和低海拔地区总体人群的平均眼压相当。
