Belenichev I, Burlaka B, Puzyrenko A, Ryzhenko O, Kurochkin M, Yusuf J
Zaporozhye State Medical University, 1Department of Pharmacology and Medical Recipe.
Zaporozhye State Medical University, 2Department of Drug Technology.
Georgian Med News. 2019 Sep(294):141-145.
General anesthesia may cause damage of the central nervous system and cognitive dysfunction in the postoperative period. A new intranasal form of Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester) was developed by our team at the Department of the medical technology (Zaporizhzhia State Medical University, Ukraine). The objectives of this investigation were the study of neuroprotective action of Noopept and to prove using in the clinic for correction of amnestic and behavioral disorders after ketamine anesthesia. We discovered that the intranasal administration of noopept after ketamine anesthesia significantly decreases anxiety and excitability, raises the animal's activity, shows an intensive antiamnesic effects and increases animal's training ability. Noopept significantly exceeds piracetam and cerebrocurin according to neuroprotective effects.
全身麻醉可能会导致中枢神经系统损伤以及术后认知功能障碍。我们团队（乌克兰扎波罗热国立医科大学医学技术系）研发出了一种新的鼻内用诺肽普（N-苯基乙酰基-L-脯氨酰甘氨酸乙酯）。本研究的目的是探究诺肽普的神经保护作用，并证明其在临床上用于纠正氯胺酮麻醉后失忆和行为障碍的可行性。我们发现，氯胺酮麻醉后经鼻给予诺肽普可显著降低焦虑和兴奋性，提高动物的活动能力，具有强烈的抗遗忘作用，并增强动物的训练能力。根据神经保护作用，诺肽普明显优于吡拉西坦和脑复素。
