Gao Yan-Hang, Li Qing-Quan, Wang Chun-Guang, Sun Jing, Wang Xiao-Mei, Li Ya-Jun, He Xiu-Ting, Xu Hong-Qin, Niu Jun-Qi
Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun.
Department of Gastroenterology, The Hospital of CNOOC, Tianjin.
Medicine (Baltimore). 2019 Nov;98(44):e17867. doi: 10.1097/MD.0000000000017867.
Interleukin(IL)-22 plays an important role in promoting liver regeneration and repair, but its role in chronic HBV-related liver diseasesis not clear. The goal of this study was to evaluate associations between eight IL22 single nucleotide polymorphisms (SNPs) and the development of chronic HBV cirrhosis and HBV-related HCC within a Chinese Han population.
We investigated associations between single nucleotide polymorphisms (SNPs) in the IL22 gene (rs1026788, rs2227472, rs2227491, rs2227485, rs1179249, rs2046068,rs2227473, and rs7314777) and the risk of HBV-related chronic liver diseases within a Han population in Northeast China. A total of 649 participants were included in the study, including 103 patients with CHB, 264 patients with LC, and 282 patients with HCC. The odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated using chi-square test. Haplotype analysis was conducted by haploview software.
Genotype and allele distributions of SNPs rs1179249 and rs2227472 differed between LC and CHB groups (both P < 0.05).The G alleles of SNP rs2227491 and rs1026788 were more frequent in the LC group than in the CHB group (P = 0.046, P = 0.041 respectively). A IL22 haplotype consisting of the minor alleles of SNP rs1179249 and the major alleles of seven other SNPs occurred less frequently in the LC and HCC groups than in the CHB group (28.2%, 33.94%, and 37.86%, respectively, P < 0.05). Moreover, there were no significant associations between smoking or drinking and IL22 SNPs on the risk of HCC (P > 0.05).
IL22 genetic variations were associated with chronic HBV infection progression, especially in the HBV-LC group. The IL22 genetic variations may help clinicians initiate the correct treatment strategy at the CHB stage.
白细胞介素（IL）-22在促进肝脏再生和修复中发挥重要作用，但其在慢性乙型肝炎病毒（HBV）相关肝病中的作用尚不清楚。本研究旨在评估中国汉族人群中8个IL22单核苷酸多态性（SNP）与慢性HBV肝硬化及HBV相关肝细胞癌（HCC）发生之间的关联。
我们调查了IL22基因中的单核苷酸多态性（SNP）（rs1026788、rs2227472、rs2227491、rs2227485、rs1179249、rs2046068、rs2227473和rs7314777）与中国东北汉族人群中HBV相关慢性肝病风险之间的关系。本研究共纳入649名参与者，包括103例慢性乙型肝炎（CHB）患者、264例肝硬化（LC）患者和282例HCC患者。采用卡方检验计算比值比（OR）及相应的95%置信区间（CI）。使用Haploview软件进行单倍型分析。
rs1179249和rs2227472的基因型和等位基因分布在LC组和CHB组之间存在差异（均P<0.05）。SNP rs2227491和rs1026788的G等位基因在LC组中的频率高于CHB组（分别为P=0.046，P=0.041）。由SNP rs1179249的次要等位基因和其他7个SNP的主要等位基因组成的IL22单倍型在LC组和HCC组中的出现频率低于CHB组（分别为28.2%、33.94%和37.86%，P < 0.05）。此外，吸烟或饮酒与IL22 SNP对HCC风险的影响之间无显著关联（P>0.05）。
IL22基因变异与慢性HBV感染进展相关，尤其是在HBV-LC组。IL22基因变异可能有助于临床医生在CHB阶段制定正确的治疗策略。
