Department of Gynecology and Obstetrics, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fetal Pediatr Pathol. 2020 Dec;39(6):518-532. doi: 10.1080/15513815.2019.1683919. Epub 2019 Nov 6.
Previous studies have reported the association between IL-10 -1082 G > A polymorphism and preeclampsia risk, but the results remained controversial. Therefore, this meta-analysis was performed to evaluate the association of IL-10 -1082 G > A polymorphism with preeclampsia risk. We searched PubMed, ISI Web of Knowledge and CNKI databases to identify eligible studies up to September 05, 2019. A total of 21 case-control studies with 3,510 cases and 5,874 controls were selected. The results revealed that IL-10 -1082 G > A polymorphism was significantly associated with an increased risk of preeclampsia under the recessive model (AA vs. AG + GG: OR = 1.191, 95% CI = 1.018-1.394, = 0.029). Stratified analyses by ethnicity revealed a significantly increased risk of preeclampsia in Asian and mixed populations, but not in Caucasians. Moreover, there was a significant association among Chinese and Brazilian. Our results showed that IL-10 -1082 G > A polymorphism was significantly associated with an increased risk of preeclampsia.
先前的研究报告称，IL-10 -1082 G > A 多态性与子痫前期风险之间存在关联，但结果仍存在争议。因此，进行了这项荟萃分析，以评估 IL-10 -1082 G > A 多态性与子痫前期风险之间的关联。我们检索了 PubMed、ISI Web of Knowledge 和中国知网数据库，以确定截至 2019 年 9 月 5 日的合格研究。共纳入了 21 项病例对照研究，包括 3510 例病例和 5874 例对照。结果表明，在隐性模型下，IL-10 -1082 G > A 多态性与子痫前期风险增加显著相关（AA 与 AG + GG：OR = 1.191，95%CI = 1.018-1.394， = 0.029）。按种族进行分层分析显示，亚洲人和混合人群的子痫前期风险显著增加，但白种人则不然。此外，中国和巴西人群之间存在显著关联。我们的结果表明，IL-10 -1082 G > A 多态性与子痫前期风险增加显著相关。
