College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China.
College of Animal Science, Tibet Agriculture and Animal Husbandry College, Linzhi, Tibet, 860000, China.
Sci Rep. 2019 Nov 5;9(1):16037. doi: 10.1038/s41598-019-52514-w.
Chickens reared in high altitude regions suffer from a high mortality, possibly due to poor immune responses induced by hypoxia. This experiment was conducted to evaluate whether increasing the oxygen level or administration of a probiotic could improve mortality and immune response of chickens at high altitude (2,986 m above the sea level). One-d-old chickens were randomly allocated to 1 of 6 treatments in a 2 × 3 factorial arrangement. The first factor was the oxygen level (low and high), while the second factor was the diet (basal diet, basal diet containing aureomycin, and basal diet plus L. plantarum). Increasing the oxygen level significantly reduced the mortality and improved immune responses. The levels of IgA, IgG, IL-10 and anti-BSA antibodies were significantly higher, while IL-1β, LITAF were significantly lower in chickens reared in the high-oxygen room. In the low-oxygen room, L. plantarum significantly decreased the mortality of chickens compared with the other 2 groups. Moreover, L. plantarum significantly increased the levels of IgA, anti-BSA antibodies, IL-10 and decreased IL-1β, LITAF compared with the control group. These results demonstrated that increasing oxygen level or administration of L. plantarum can improve health status of chickens in high altitude regions.
在高海拔地区饲养的鸡死亡率较高，可能是由于缺氧导致免疫反应不良。本实验旨在评估增加氧气水平或给予益生菌是否可以改善高海拔（海拔 2986 米以上）地区鸡的死亡率和免疫反应。1 日龄鸡随机分为 6 个处理组的 2×3 析因设计。第一个因素是氧气水平（低和高），第二个因素是饮食（基础饮食、含金霉素的基础饮食和添加 L. plantarum 的基础饮食）。增加氧气水平可显著降低死亡率并改善免疫反应。在高氧室中饲养的鸡的 IgA、IgG、IL-10 和抗 BSA 抗体水平显著升高，而 IL-1β、LITAF 水平显著降低。在低氧室中，与其他两组相比，L. plantarum 显著降低了鸡的死亡率。此外，与对照组相比，L. plantarum 显著增加了 IgA、抗 BSA 抗体、IL-10 的水平，降低了 IL-1β、LITAF 的水平。这些结果表明，增加氧气水平或给予 L. plantarum 可以改善高海拔地区鸡的健康状况。
