Institute of Pharmacology, University of Bern, Bern, Switzerland.
Institute of Pharmacology, University of Bern, Bern, Switzerland,
Int Arch Allergy Immunol. 2019;180(4):235-243. doi: 10.1159/000504439. Epub 2019 Nov 6.
Over the last decades, an increasing appearance of allergies and atopic disorders, such as asthma, dermatitis, and rhinitis, has been observed. The mechanisms of these disorders remain unclear, and therefore the development of novel therapies is limited. Current treatments are often symptomatic, nonspecific, or may have severe side effects. Further insights into the mechanisms of the underlying disease pathogenesis could reveal novel targets for treatment. In this review, we provide an update on recent basic and translational studies that offer novel insights and opportunities for the treatment of patients with atopic disorders.
在过去的几十年中，人们观察到过敏和特应性疾病（如哮喘、皮炎和鼻炎）的发病率不断上升。这些疾病的发病机制尚不清楚，因此新型疗法的发展受到限制。目前的治疗方法往往是对症治疗、非特异性的，或者可能有严重的副作用。进一步深入了解潜在疾病发病机制的机制可能会为治疗特应性疾病患者提供新的靶点。在这篇综述中，我们提供了最近的基础和转化研究的最新进展，这些研究为特应性疾病患者的治疗提供了新的见解和机会。
