Di Lorenzo C, Williams C M, Hajnal F, Valenzuela J E
Department of Medicine, Los Angeles County-University of Southern California Medical Center.
Gastroenterology. 1988 Nov;95(5):1211-5. doi: 10.1016/0016-5085(88)90352-6.
As pectin delays gastric emptying in normal subjects and satiety may be linked to the rate of gastric emptying, we designed this study to evaluate, in a group of obese subjects, the effect of adding pectin to a meal on gastric emptying, sensation of satiety, and postprandial plasma cholecystokinin and pancreatic polypeptide levels. We studied gastric emptying of solids in 9 adult obese subjects on 2 separate days in a randomized fashion. On day 1, 15 g of pectin was added to the meal, and on day 2 15 g of methylcellulose was added and served as control. Satiety was evaluated by an analogue rating scale. Pectin significantly delayed gastric emptying time [t1/2 = 116 +/- 23 min vs. 71 +/- 17 min observed with methylcellulose (p less than 0.001)]. Pectin also significantly increased subjects' sensation of satiety [98 +/- 7 vs. 74 +/- 17 (p less than 0.001)]. Postprandial release of cholecystokinin and pancreatic polypeptide was not modified by pectin. As pectin induces satiety and delays gastric emptying in obese patients, it may be a useful adjuvant in the treatment of disorders of overeating.
由于果胶可延缓正常受试者的胃排空，而饱腹感可能与胃排空速率有关，我们设计了本研究，以评估在一组肥胖受试者中，进餐时添加果胶对胃排空、饱腹感以及餐后血浆胆囊收缩素和胰多肽水平的影响。我们以随机方式，在2个不同日期对9名成年肥胖受试者的固体胃排空情况进行了研究。第1天，进餐时添加15克果胶，第2天添加15克甲基纤维素作为对照。通过模拟评分量表评估饱腹感。果胶显著延迟了胃排空时间[t1/2 = 116 +/- 23分钟，而甲基纤维素组为71 +/- 17分钟（p < 0.001）]。果胶还显著增强了受试者的饱腹感[98 +/- 7，而甲基纤维素组为74 +/- 17（p < 0.001）]。果胶对餐后胆囊收缩素和胰多肽的释放没有影响。由于果胶可诱导肥胖患者产生饱腹感并延缓胃排空，它可能是治疗暴饮暴食症的一种有用辅助剂。
