Koufopoulos Nektarios, Antoniadou Foteini, Kokkali Stefania, Pigadioti Eleni, Khaldi Lubna
Pathology, Attikon University Hospital, Medical School of Athens, Athens, GRC.
Pathology, Saint Savvas Cancer Hospital, Athens, GRC.
Cureus. 2019 Sep 1;11(9):e5550. doi: 10.7759/cureus.5550.
Invasive lobular carcinoma of the breast is the second most common subtype of breast carcinoma. It accounts for 5-15% of the breast carcinoma cases reported. It shows a different metastatic pattern compared to invasive carcinoma of no special type. There are several variants of this cancer including the classic, solid, signet ring cell, tubulolobular, alveolar, trabecular, pleomorphic, and mixed subtypes each one with a distinctive morphology. Invasive lobular carcinoma has been associated with intracellular mucin production, in the form of intracytoplasmic lumina and signet ring cells whereas extracellular mucin production has been related to carcinomas of ductal origin. A new variant that displays extracellular mucin production was described recently. Only nineteen cases of this rare entity have been reported to date. In this manuscript, we report an additional case of invasive lobular carcinoma with extracellular mucin production, describing its clinico-pathological characteristics, and review the literature on the same.
乳腺浸润性小叶癌是乳腺癌的第二常见亚型。它占报告的乳腺癌病例的5-15%。与非特殊类型的浸润性癌相比，它表现出不同的转移模式。这种癌症有几种变体，包括经典型、实体型、印戒细胞型、小管小叶型、肺泡型、小梁型、多形型和混合型亚型，每种都有独特的形态。乳腺浸润性小叶癌与细胞内粘蛋白的产生有关，表现为胞质内腔和印戒细胞的形式，而细胞外粘蛋白的产生与导管起源的癌有关。最近描述了一种显示细胞外粘蛋白产生的新变体。迄今为止，仅报道了19例这种罕见实体。在本手稿中，我们报告了另一例伴有细胞外粘蛋白产生的乳腺浸润性小叶癌病例，描述了其临床病理特征，并对相关文献进行了综述。
