Koufopoulos Nektarios, Pateras Ioannis S, Gouloumis Alina Roxana, Ieronimaki Argyro Ioanna, Zacharatou Andriani, Spathis Aris, Leventakou Danai, Economopoulou Panagiota, Psyrri Amanda, Arkadopoulos Nikolaos, Panayiotides Ioannis G
Second Department of Pathology, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Chaidari, 12462 Athens, Greece.
Medical Oncology Unit, 2nd Department of Internal Medicine-Propaedeutic, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Chaidari, 12462 Athens, Greece.
Diagnostics (Basel). 2022 Nov 1;12(11):2658. doi: 10.3390/diagnostics12112658.
Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and β-catenin staining) features. Moreover, ILC displays a poor response to neoadjuvant therapy, a different metastatic pattern compared to invasive breast carcinoma of no special type, as well as unique molecular characteristics. In addition to the classic variant of invasive lobular carcinoma, several other well-recognized variants exist, including classic, alveolar, tubulolobular, solid, pleomorphic, signet-ring, and mixed. Furthermore, three novel variants of invasive lobular carcinoma, i.e., with extracellular mucin production, papillary features, and tubular elements, have been described during the last decade. We herewith focus on the unique morphological and immunohistochemical characteristics of these novel varieties of invasive lobular carcinoma, as well as differential diagnostic considerations and potential diagnostic pitfalls, especially when dealing with biopsy specimens.
浸润性小叶癌是最常见的特殊型乳腺癌亚型，具有独特的形态学特征（细胞黏附性差、单细胞条索状、靶样模式）和免疫组化特征（E-钙黏蛋白和β-连环蛋白染色缺失）。此外，浸润性小叶癌对新辅助治疗反应不佳，与非特殊类型浸润性乳腺癌相比转移模式不同，且具有独特的分子特征。除了浸润性小叶癌的经典变体，还存在其他几种公认的变体，包括经典型、腺泡型、小管小叶型、实体型、多形性、印戒型和混合型。此外，在过去十年中描述了浸润性小叶癌的三种新变体，即伴有细胞外黏液产生、乳头状特征和小管成分。我们在此重点关注这些新型浸润性小叶癌的独特形态学和免疫组化特征，以及鉴别诊断要点和潜在的诊断陷阱，尤其是在处理活检标本时。
